Piotr Paduszyński

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Reactive oxygen species (ROS) include a number of chemically reactive molecules derived from oxygen. ROS such as superoxide, hydrogen peroxide, and lipid hydroperoxides are known to modulate cell proliferation and apoptosis, and induce synthesis of growth factors that play an important role in tumor growth and invasion. Anticancer drugs such as doxorubicin(More)
In cartilage tissue regeneration, it is important to develop biodegradable scaffolds that provide a structural and logistic template for three-dimensional cultures of chondrocytes. In this study, we evaluated changes in expression of cartilaginous genes during in vitro chondrogenic differentiation of WJ-MSCs on PLGA scaffolds. The biocompatibility of the(More)
In this study, we evaluated the usefulness of two commercially available hyaluronic acid-based hydrogels, HyStem and HyStem-C, for the cultivation of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) and their differentiation towards chondrocytes. The WJ-MSCs were isolated from umbilical cord Wharton’s jelly using the explant method and their immunophenotype(More)
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