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We have investigated the question whether during chromosomal DNA replication in Escherichia coli the two DNA strands may be replicated with differential accuracy. This possibility of differential replication fidelity arises from the distinct modes of replication in the two strands, one strand (the leading strand) being synthesized continuously, the other(More)
To preserve genome integrity, the S-phase checkpoint senses damaged DNA or nucleotide depletion and when necessary, arrests replication progression and delays cell division. Previous studies, based on two pol2 mutants have suggested the involvement of DNA polymerase epsilon (Pol ε) in sensing DNA replication accuracy in Saccharomyces cerevisiae. Here we(More)
Genetic interactions of the Aspergillus nidulans atmA ATM homolog with different components of the DNA damage response pathway .. AND HIROSHI MITANI, Rescue from oculocutaneous albinism type 4 using medaka slc45a2 cDNA driven by its own promoter .. Recessive black is allelic to the yellow plumage locus in Japanese quail and associated with a frameshift(More)
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