Learn More
The National Science and Technology Council (NSTC) is the principal means by which the Executive Branch coordinates science and technology policy across the diverse entities that make up the Federal research and development enterprise. A primary objective of the NSTC is establishing clear national goals for Federal science and technology investments. The(More)
Historically, treatment of patients with cancer using chemotherapeutic agents has been associated with debilitating and systemic toxicities, poor bioavailability, and unfavorable pharmacokinetics. Nanotechnology-based drug delivery systems, on the other hand, can specifically target cancer cells while avoiding their healthy neighbors, avoid rapid clearance(More)
A fully integrated biochip device that consists of microfluidic mixers, valves, pumps, channels, chambers, heaters, and DNA microarray sensors was developed to perform DNA analysis of complex biological sample solutions. Sample preparation (including magnetic bead-based cell capture, cell preconcentration and purification, and cell lysis), polymerase chain(More)
Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor interstitial space, whereas the suppressed lymphatic filtration allows them to stay there. This phenomenon, enhanced permeability and retention (EPR), has been the basis of nanotechnology platforms to deliver drugs to tumors. However, progress in developing effective(More)
—Dynamic beam switching of vertical-cavity surface-emitting lasers (VCSEL's) have been demonstrated for the first time using integrated optical beam routers. The output beam of the VCSEL is switched electrically between two different emission angles. High-speed switching up to 2 GHz has been achieved with an 8 m 2 8 m device. Such beam-steering devices are(More)
Peptides and proteins find an ever-increasing number of applications in the biomedical and materials engineering fields. The use of non-proteinogenic amino acids endowed with diverse physicochemical and structural features opens the possibility to design proteins and peptides with novel properties and functions. Moreover, non-proteinogenic residues are(More)
the modulation between 0 V and-4.3 V, in light of chirp and saturation considerations. The first mode of operation yields slightly negative chirp, whereas the second yields positive chirp. The optical saturation and carrier accumulation effects are much weaker in the first due to reduced coupling between optical fields and excitons, and due to more(More)
We report the first fabrication of a vertical three-dimensional 8 x 1 micro-Fresnel lens array by surface micromachining technique and we also demonstrate the hybrid integration of the micro-Fresnel lens array with a passively aligned 8 x 1 vertical cavity surface emitting laser (VCSEL) array on the same silicon substrate. The fabrication and(More)