Piotr Czupryna

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PURPOSE Knowledge of the role of chemokines in the inflammation during neuroborreliosis (NB) is limited. We evaluated the pre- and post-treatment concentration of CXCL8, CXCL10, CXCL11, CXCL12, and CXCL13 in serum (s) and cerebrospinal fluid (csf) in patients with NB. RESULTS There was a statistically significant increase in pre-treatment s CXCL8, CXCL10,(More)
PURPOSE The aim of the study was to assess the concentration of chemokines: CXCL10, XCL11, CXCL12, CXCL13 in serum and cerebrospinal fluid (CSF) in patients with tick-borne encephalitis (TBE) before and after treatment. We evaluated also the usefulness of these molecules in diagnosis and monitoring of inflammation in TBE. METHODS Twenty three patients(More)
AIM The aim of the study was the detection of WNV RNA in cerebrospinal fluid of patients with lymphocytic meningitis. MATERIAL AND METHODS Samples of cerebrospinal fluid from 24 patients hospitalized in the Department of Infectious Diseases and Neuroinfections between May and September because of meningitis were evaluated concerning presence of WNV RNA.(More)
Lyme disease is a chronic tick borne disease, caused by spirochetes B. burgdorferi. The condition influences mostly on skin, nervous system, skeletal system and circulatory system. Recently more and more reports of so called "Post Lyme syndrome (PLS)" have appeared. PLS is a new clinical, diagnostic and therapeutic problem connected with patients with a(More)
Tick-borne encephalitis (TBE) has a wide clinical spectrum, from asymptomatic to severe encephalitis, and host-dependent factors determining the outcome remain elusive. We have measured concentrations of pro-inflammatory/Th1 interferon-γ (IFNγ), immunomodulatory/Th2 interleukin-10 (IL-10), anti-viral type I (IFNβ) and type III (IFNλ3) interferons in(More)
BACKGROUND AND PURPOSE Tick-borne encephalitis (TBE) is an emerging disease in Europe as in Poland, especially in north-eastern part of the country. The aim of the study was to characterize the epidemiology and clinical features of TBE in this region. METHODS Clinical and epidemiological data of 687 patients hospitalized between 1993 and 2008 at the(More)
Chemokine receptor 5 (CCR5) is hypothesized to drive the lymphocyte migration to central nervous system in flavivirus encephalitis, and the non-functional CCR5Δ32 genetic variant was identified as a risk factor of a West Nile virus infection and of tick-borne encephalitis (TBE). We have attempted to investigate how CCR5 expression corresponds to the(More)
Tularemia is a rare zoonosis. The most common way is ingestion of contaminated meat or water, but the infection may also be acquired by insect bite. The clinical picture of the disease may be nonspecific. Due to polymorphisms of clinical picture, specific treatment is often delayed. In the last 50 years, in Poland, the most infections were acquired by(More)
BACKGROUND Human babesiosis caused by Babesia microti and Babesia divergens parasites is an emerging tick-borne disease worldwide. The prevalence of infection and frequency of the disease caused by B. microti in Europe is not well known. The aim of our study was to evaluate the frequency of anti-B. microti antibodies in the serum of forest employees (a(More)