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The nucleolus has emerged as a key player that regulates cell growth, survival and the recovery from stress. Progress in proteomics made it possible to sequence the nucleolar proteome under different physiological conditions. Together with other research, this work revealed the presence of multiple chaperones and co-chaperones in the nucleolus. Molecular(More)
We present the annotation architecture of the National Corpus of Polish and discuss problems identified in the TEI stand-off annotation system, which, in its current version, is still very much unfinished and untested, due to both technical reasons (lack of tools implementing the TEI-defined XPointer schemes) and certain problems concerning data(More)
Hsc70s are constitutively synthesized members of the 70-kDa chaperone family; they are essential for viability and conserved among all organisms. When eukaryotic cells recover from stress, hsc70s accumulate in nucleoli by an unknown mechanism. Our studies were undertaken to characterize the signaling events and the targeting sequence required to concentrate(More)
Nucleoli are composed of possibly several thousand different proteins and represent the most conspicuous compartments in the nucleus; they play a crucial role in the proper execution of many cellular processes. As such, nucleoli carry out ribosome biogenesis and sequester or associate with key molecules that regulate cell cycle progression, tumorigenesis,(More)
The physiological state of eukaryotic cells controls nuclear trafficking of numerous cargos. For example, stress results in the inhibition of classical protein import, which is characterized by the redistribution of several transport factors. As such, importin-α and cellular apoptosis susceptibility protein (CAS) accumulate in nuclei of heat-shocked cells;(More)
This article describes POLIQARP, a corpus indexing and query tool, which understands positional tagsets and which does not assume that word forms are annotated with unique morphosyntactic tags. POLIQARP is designed to be applicable to a variety of languages and tagsets: it works with XML-encoded texts, uses the UTF-8 character set, and allows for an(More)
ERK and Akt kinases are key components that participate in numerous regulatory processes, including the response to stress. Using novel tools for quantitative immunofluorescence, we show that oxidant exposure controls the intracellular activation and localization of ERK1/2 and Akt. Oxidative stress alters the nuclear/cytoplasmic levels of the kinases,(More)
The present article describes the first stage of the KorAP project, launched recently at the Institut für Deutsche Sprache (IDS) in Mannheim, Germany. The aim of this project is to develop an innovative corpus analysis platform to tackle the increasing demands of modern linguistic research. The platform will facilitate new linguistic findings by making it(More)
Nuclear pore complexes (NPCs) provide the only sites for macromolecular transport between nucleus and cytoplasm. The nucleoporin p62, a component of higher eukaryotic NPCs, is located at the central gated channel and involved in nuclear trafficking of various cargos. p62 is organized into an N-terminal segment that contains FXFG repeats and binds the(More)