Pinpin Chu

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The in vivo metabolism and excretion of the urinary metabolites from the pyrrolizidine alkaloids (PAs), retrorsine (RET) and retrorsine-N-oxide (RET-NO) have been studied in rats. Isatinecic acid (INA), pyrrolic metabolites, N-oxides and retronecine accounted for 31.0, 10.3, 10.8 and 0.39% of the administered RET. Predosing rats with triorthocresyl(More)
BACKGROUND AND AIMS Attempts to immunize aged subjects often result in the failure to elicit a protective immune response. Murine model studies have shown that oligonucleotides containing CpG motifs (CpG ODN) can stimulate immune system in aged mice as effectively as in young mice. Since many physiological and pathophysiological data of pigs can be(More)
Mammalian peptidoglycan recognition proteins (PGLYRPs) are highly conserved pattern-recognition molecules of the innate immune system with considerable bactericidal activity, which manifest their potential values for the application to food and pharmaceutical industry. However, the effective expression of porcine PGLYRP-1 in Pichia pastoris has not been(More)
1. The urinary excretion of the metabolites, isatinecic acid and pyrrolic metabolites from the pyrrolizidine alkaloid retrosine were lower in the resistant species, guinea-pigs, than the susceptible species, mice, hamsters and rats. 2. The urinary N-oxides levels, however, were higher in guinea-pigs relative to mice, hamsters and rats. 3. These results(More)
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