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For people with type 1 diabetes, automatic controllers aim to maintain the blood glucose concentration within the desired range of 60-120 mg/dL by infusing the appropriate amount of insulin in the presence of meal and exercise disturbances. Blood glucose concentration outside the desired range can be harmful to an individual's health but concentration below(More)
An advanced model-based control technique for regulating the blood glucose for patients with Type 1 diabetes is presented. The optimal insulin delivery rate is obtained off-line as an explicit function of the current blood glucose concentration of the patient by using novel parametric programming algorithms, developed at Imperial College London. The(More)
BACKGROUND Monoclonal antibody therapy against α4β-integrin is efficacious in patients with multiple sclerosis (MS) with some safety concerns. We assessed the safety and efficacy of firategrast, a small oral anti-α4β-integrin molecule, in patients with relapsing remitting MS. METHODS We did a multicentre, phase 2, randomised, double-blind,(More)
The nerve growth factor (NGF) pathway is of great interest as a potential source of drug targets, for example in the management of certain types of pain. However, selecting targets from this pathway either by intuition or by non-contextual measures is likely to be challenging. An alternative approach is to construct a mathematical model of the system and(More)
This work presents a compartmental model for delivery of drugs under anesthesia and an advanced model based control algorithm for insulin delivery for Type 1 diabetes. The model for anesthesia involves choice of three drugs isoflurane, dopamine and sodium nitroprusside, which allows simultaneous regulation of mean arterial pressure and unconsciousness of(More)
This paper presents an advanced model based control technique for regulating the blood glucose in Type 1 diabetic patients based upon novel parametric programming algorithms, developed at Imperial College London. The optimal insulin delivery rate is obtained off-line as an explicit function of the current blood glucose level of the patient. The(More)
This work presents a compartmental model for delivery of three drugs (isoflurane, dopamine and sodium nitroprusside) for regulation of anesthesia. The key feature of this model is that mean arterial pressure, cardiac output and unconsciousness of the patient can be simultaneously regulated. This model is 'validated' by carrying out a number of dynamic state(More)