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BACKGROUND There is a wide variation in the reported prevalence of primary hyperhidrosis in the literature. Further, it is unknown if primary hyperhidrosis is a lifelong condition, or if demographical factors influence hyperhidrosis prevalence. OBJECTIVES This study aims to examine the prevalence of hyperhidrosis in multiple ethnic groups from two(More)
BACKGROUND Azithromycin has been used to treat primary and secondary syphilis and as prophylaxis for sexual partners. We evaluated syphilis treatment failure in patients who received azithromycin therapy. METHODS Patients who did not respond to azithromycin therapy were referred to Shanghai Skin Disease and sexually transmitted disease hospital. Treatment(More)
Previously, a small study showed that 14f was the predominant subtype of Treponema pallidum in Shanghai, China. The result was quite different from the genotype distribution in other areas of China. This study aimed to identify the strain types of Treponema pallidum in samples collected over a 5-year period in Shanghai. From 2007 to 2011, genital swabs were(More)
BACKGROUND Syphilis, a sexually transmitted disease caused by spirochetal bacterium Treponema pallidum, can progress to affect the central nervous system, causing neurosyphilis. Accumulating evidence suggest that regulatory T cells (Tregs) may play an important role in the pathogenesis of syphilis. However, little is known about Treg response in(More)
BACKGROUND/AIMS We investigated the clinical and cognitive features of patients with mild general paresis of the insane (GPI) in comparison to Alzheimer's disease (AD) patients, mild frontotemporal dementia (FTD) patients and normal elderly individuals. METHODS Twelve patients with mild GPI, 24 patients with mild AD, 11 patients with mild FTD and 36(More)
OBJECTIVE To evaluate the efficacy of azithromycin in preventing congenital syphilis. METHOD Five pregnant women with syphilis who were allergic to penicillin were given azithromycin, 1 g daily orally or intravenously, in different hospitals. The duration of the therapy ranged from 1 day to 10 days. A second course of therapy was provided at 28 weeks(More)
OBJECTIVES To evaluate the efficacy of ceftriaxone in pregnant women who were diagnosed with early syphilis. STUDY Eleven women with a history of penicillin allergy, positive skin test, but prior history of safe usage of cephalosporins were included. Ceftriaxone (250 mg) was given intramuscularly once daily for 7 and 10 days to patients with primary and(More)
BACKGROUND Treponema pallidum infection evokes vigorous immune responses, resulting in tissue damage. Several studies have demonstrated that IL-17 may be involved in the pathogenesis of syphilis. However, the role of Th17 response in neurosyphilis remains unclear. METHODOLOGY/PRINCIPAL FINDINGS In this study, Th17 in peripheral blood from 103(More)
OBJECTIVES To study 17 cases of secondary syphilis that progressed to neurosyphilis despite appropriate treatments and whose rapid plasma reagin (RPR) titres showed a fourfold decrease within 6 months but did not revert to negative. METHODS Secondary syphilis patients with the following criteria were analysed: (1) RPR titres declined fourfold within 3(More)
Early recognition of acquired syphilis in childhood is vital. Children may acquire syphilis as a consequence of kissing, breast-feeding, or handling. We report 2 cases of infantile syphilis transmitted by mouth-to-mouth feeding from actively infected relatives. Syphilis should be suspected in children presenting with atypical rashes accompanied by headache,(More)