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Divergent Entry to Gelsedine-Type Alkaloids: Total Syntheses of (-)-Gelsedilam, (-)-Gelsenicine, (-)-Gelsedine, and (-)-Gelsemoxonine.
- Pingluan Wang, Y. Gao, D. Ma
- Chemistry, Medicine
- Journal of the American Chemical Society
- 30 August 2018
A divergent entry to gelsedine-type alkaloids is disclosed that hinges on rapid assembly of the common core by the orchestrated application of an asymmetric Michael addition, a tandem oxidation/aldol cyclization, and a pinacol rearrangement and generation of the structural diversity via a late-stage heterocyclization. Expand