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Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway
TLDR
Curcumin alleviates fibrosis by reducing the expression of HIF-1α partly through the ERK pathway, and this study indicates that curcumin was able to attenuate liver fibrosis and inhibit the proliferation of HSC.
Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum
TLDR
Screening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal medicines and dietary supplements and excludes Toxin (heavy metals, pesticides, and mycotoxins) contamination.
Exploring an Integrative Therapy for Treating COVID-19: A Randomized Controlled Trial
TLDR
Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.
[Quality control of shuanghuanglian freeze-dried powder for injection based on its HPLC-ELSD fingerprints and biological profiles].
TLDR
It is demonstrated that the correlative detection was proposed as an efficient strategy for quality control of SFPI, based on HPLC-ELSD fingerprints and biological profiles, which could detect quality fluctuation of samples early and quickly and predict the potential adverse drug events (ADE) for ensuring clinical safety.
Microcalorimetry coupled with principal component analysis for investigating the anti-Staphylococcus aureus effects of different extracted fractions from Dracontomelon dao
With the prevalence resistance of Staphylococcus aureus to antibacterial agents, developing novel antibacterial agents is urgent. Recently, plant extracts have got more focus. In this study, the
Paeoniflorin protects against ANIT-induced cholestasis by ameliorating oxidative stress in rats.
Colorimetric Grading Scale Can Promote the Standardization of Experiential and Sensory Evaluation in Quality Control of Traditional Chinese Medicines
TLDR
This work illustrates the technical feasibility of the color-based grading of rhubarb quality and offers references for quantifying and standardizing the sensory evaluation of TCMs, foods and other products.
Beneficial clinical effects of grape seed proanthocyanidin extract on the progression of carotid atherosclerotic plaques
TLDR
GSPE inhibited the progression of MMCIMT and reduced carotid plaque size in GSPE treated patients, and with extended treatment, the superior efficacy on MMC IMT and carOTid plaque occurred.
Evaluation of the liver protection and toxicity of Da-Huang-Zhe-Chong pill in rats
TLDR
The results showed that DHZCP exhibited a significant protective effect on liver injury by reversing the biochemical parameters and histopathological changes, however, this hepatoprotective effect may be weakened, or even be transferred to toxicity with the increase of the administration dose and time of this formula.
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