Cytoplasm contains important metabolism reaction organelles such as mitochondria and chloroplast (in plant). In particular, mitochondria contains special DNA information which can be passed to offsprings through maternal gametes, and has been confirmed to play a pivotal role in nuclear activities. Experimental evidences have documented the importance of… (More)
Single variant analysis in genome-wide association studies (GWAS) has been proven to be successful in identifying thousands of genetic variants associated with hundreds of complex diseases. However, these identified variants only explain a small fraction of inheritable variability in many diseases, suggesting that other resources, such as multilevel genetic… (More)
The genetic basis of blood pressure often involves multiple genetic factors and their interactions with environmental factors. Gene-environment interaction is assumed to play an important role in determining individual blood pressure variability. Older people are more prone to high blood pressure than younger ones and the risk may not display a linear trend… (More)
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Gene-environment (G×E) interaction plays a pivotal role in understanding the genetic basis of complex disease. When environment factors are measured in a continuous scale, one can assess the genetic sensitivity over different environmental conditions on a disease phenotype. Motivated by the increasing awareness of the power of gene set based association… (More)