Ping-Ping Kuang

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We previously showed that interleukin-1β (IL-1β) decreased elastin gene transcription through activation of the NF-κB subunit p65 in neonatal rat lung fibroblasts. The present study was undertaken to further explore the molecular mechanisms responsible for the inhibitory effect of IL-1β on elastin gene transcription. We found that cycloheximide blocked(More)
Elastin synthesis is essential for lung development and postnatal maturation as well as for repair following injury. Using human embryonic lung fibroblasts that express undetectable levels of elastin as assessed by Northern analyses, we found that treatment with exogenous transforming growth factor-(TGF-) induced rapid and transient increases in levels of(More)
Differentiation of lung vascular smooth muscle cells (vSMCs) is tightly regulated during development or in response to challenges in a vessel specific manner. Aberrant vSMCs specifically associated with distal pulmonary arteries have been implicated in the pathogenesis of respiratory diseases, such as pulmonary arterial hypertension (PAH), a progressive and(More)
Interstitial fibroblasts are an integral component of the alveolar wall. These cells produce matrix proteins that maintain the extracellular scaffold of alveolar structures. Emphysema is characterized by airspace enlargement resulting from the loss of alveolar cellularity and matrix. In this study, we explored the endotracheal delivery of fibroblasts to the(More)
phosphatidylinositol 3-kinase activity and β Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-β expression of the transcription factor C/EBP-lactone increases the β Treatment of cultured myotubes with the proteasome inhibitor mechanism of inhibition of SP-B gene expression Proteasome dysfunction inhibits surfactant protein gene(More)
myofibroblasts FGF-18 is upregulated in the postnatal rat lung and enhances elastogenesis in including high-resolution figures, can be found at: Updated information and services integrative aspects of normal and abnormal function of cells and components of the respiratory system. It is published 12 times a publishes original research covering the broad(More)
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