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Both insulin resistance (type II diabetes) and beta-amyloid (Abeta) oligomers are implicated in Alzheimer's disease (AD). Here, we investigate the role of Abeta oligomer-induced c-Jun N-terminal kinase (JNK) activation leading to phosphorylation and degradation of the adaptor protein insulin receptor substrate-1 (IRS-1). IRS-1 couples insulin and other(More)
Hyperphosphorylation and accumulation of tau aggregates are prominent features in tauopathies, including Alzheimer's disease, but the impact of loss of tau function on synaptic and cognitive deficits remains poorly understood. We report that old (19-20 months; OKO) but not middle-aged (8-9 months; MKO) tau knock-out mice develop Morris Water Maze (MWM)(More)
1 Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic and behavioral deficits in aged human tau transgenic mice Background: Various types of tau aggregates in AD brains may differentially impact neurodegeneration. Results: Curcumin selectively suppresses soluble tau dimers and corrects molecular chaperone, synaptic and(More)
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