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Structural modulation of gut microbiota in life-long calorie-restricted mice
Calorie restriction has been regarded as the only experimental regimen that can effectively lengthen lifespan in various animal models, but the actual mechanism remains controversial. The gutExpand
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Discovery of XL413, a potent and selective CDC7 inhibitor.
CDC7 is a serine/threonine kinase that has been shown to be required for the initiation and maintenance of DNA replication. Up-regulation of CDC7 is detected in multiple tumor cell lines, withExpand
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Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug-drug conjugate for cancer therapy.
All drugs for cancer therapy face several transportation barriers on their tortuous journey to the action sites. To overcome these barriers, an effective drug delivery system for cancer therapy isExpand
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Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy.
A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as capsExpand
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MicroRNA-17/20a inhibits glucocorticoid-induced osteoclast differentiation and function through targeting RANKL expression in osteoblast cells.
Glucocorticoids act on the osteoblasts to up-regulate the expression of RANKL, which is very important in the etiology of glucocorticoid-induced osteoclast differentiation and bone resorption. TheExpand
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Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts.
One of the greatest barriers to the treatment of cancer with chemotherapeutic drugs is acquisition of drug resistance. This includes multidrug resistance mediated by P-glycoprotein (Pgp) to multipleExpand
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Onset of tethered chain overcrowding.
We proposed an approach to precisely control the density of tethered chains on solid substrates using PEO-b-PS and PLLA-b-PS. As the crystallization temperature Tx increased, the PEO or PLLA lamellarExpand
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Near-infrared quantum cutting in transparent nanostructured glass ceramics.
Quantum cutting downconversion involving the emission of two near-infrared photons for each blue photon absorbed is realized in transparent glass ceramics with embedded Pr3+/Yb3+: beta-YF3Expand
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Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity
Mediator complex is a molecular hub integrating signaling, transcription factors, and RNA polymerase II (RNAPII) machinery. Mediator MED23 is involved in adipogenesis and smooth muscle cellExpand
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Anti-hyperuricemic and nephroprotective effects of Modified Simiao Decoction in hyperuricemic mice.
ETHNOPHARMACOLOGICAL RELEVANCE Modified Simiao Decoction (MSD), based on clinical experience, has been used for decades and famous for its efficiency in treating hyperuricemic and gouty diseases. Expand
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