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Alternative transcription initiation leads to expression of a novel ALK isoform in cancer
Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplasticExpand
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Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
An oncohistone deranges inhibitory chromatin Missense mutations (that change one amino acid for another) in histone H3 can produce a so-called oncohistone and are found in a number of pediatricExpand
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Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST
Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit combined inactivation of NF1, CDKN2A, and polycomb repressive complex 2 component genes (Embryonic Ectoderm Development [EED] andExpand
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Hormone Activity of Hydroxylated Polybrominated Diphenyl Ethers on Human Thyroid Receptor-β: In Vitro and In Silico Investigations
  • Fei Li, Q. Xie, +5 authors Ce Hao
  • Chemistry, Medicine
  • Environmental health perspectives
  • 17 December 2009
Background Hydroxylated polybrominated diphenyl ethers (HO-PBDEs) may disrupt thyroid hormone status because of their structural similarity to thyroid hormone. However, the molecular mechanisms ofExpand
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Estrogenic activity of anthraquinone derivatives: in vitro and in silico studies.
Comprehension of the ligand-receptor interactions is a prerequisite for constructing mechanism based quantitative structure-activity relationship (QSAR) models on xenoestrogenic activity. MolecularExpand
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Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab
Purpose: A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating thatExpand
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Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes.
Recent studies have shown that mutations at non-coding elements, such as promoters and enhancers, can act as cancer drivers. However, an important class of non-coding elements, namely CTCFExpand
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Synthesis and properties of chitosan/polypeptide bioconjugate composite.
Adhesive polypeptide containing the key component of mussel adhesive protein was synthesized by ring-opening polymerization, and a hybrid material of the adhesive polypeptide and chitosan wasExpand
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Phase 2 study of the CDK4 inhibitor abemaciclib in dedifferentiated liposarcoma.
11004Background: The oncogene cyclin-dependent kinase 4 (CDK4) is amplified in > 90% of de-differentiated liposarcomas (DDLS). We previously demonstrated that treatment with the CDK4 inhibitor palb...
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Aggregate formation and surface activity of partially deacetylated water-soluble chitin
Water-soluble chitin (WSC), partially acetylated, was prepared by using N-acetylation in mild conditions. The aggregation behavior of WSC in aqueous solution was investigated. the results showed thatExpand
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