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Alternative transcription initiation leads to expression of a novel ALK isoform in cancer
Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplastic… Expand
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
An oncohistone deranges inhibitory chromatin Missense mutations (that change one amino acid for another) in histone H3 can produce a so-called oncohistone and are found in a number of pediatric… Expand
Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST
- Carlos N. Prieto-Granada, Thomas Wiesner, J. Messina, A. Jungbluth, Ping Chi, C. Antonescu
- Biology, Medicine
- The American journal of surgical pathology
- 1 April 2016
Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit combined inactivation of NF1, CDKN2A, and polycomb repressive complex 2 component genes (Embryonic Ectoderm Development [EED] and… Expand
Hormone Activity of Hydroxylated Polybrominated Diphenyl Ethers on Human Thyroid Receptor-β: In Vitro and In Silico Investigations
- Fei Li, Q. Xie, +5 authors Ce Hao
- Chemistry, Medicine
- Environmental health perspectives
- 17 December 2009
Background Hydroxylated polybrominated diphenyl ethers (HO-PBDEs) may disrupt thyroid hormone status because of their structural similarity to thyroid hormone. However, the molecular mechanisms of… Expand
Estrogenic activity of anthraquinone derivatives: in vitro and in silico studies.
- F. Li, Xiyou Li, Jianping Shao, Ping Chi, J. Chen, Zi-jian Wang
- Chemistry, Medicine
- Chemical research in toxicology
- 20 July 2010
Comprehension of the ligand-receptor interactions is a prerequisite for constructing mechanism based quantitative structure-activity relationship (QSAR) models on xenoestrogenic activity. Molecular… Expand
Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab
Purpose: A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating that… Expand
Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes.
- Eric M. Liu, Alexander Martínez-Fundichely, +9 authors E. Khurana
- Medicine, Biology
- Cell systems
- 8 May 2019
Recent studies have shown that mutations at non-coding elements, such as promoters and enhancers, can act as cancer drivers. However, an important class of non-coding elements, namely CTCF… Expand
Synthesis and properties of chitosan/polypeptide bioconjugate composite.
- J. Wang, C. Liu, J. Wei, Ping Chi, X. Lu, M. Yin
- Medicine, Materials Science
- Biomedical materials
- 19 January 2007
Adhesive polypeptide containing the key component of mussel adhesive protein was synthesized by ring-opening polymerization, and a hybrid material of the adhesive polypeptide and chitosan was… Expand
Phase 2 study of the CDK4 inhibitor abemaciclib in dedifferentiated liposarcoma.
11004Background: The oncogene cyclin-dependent kinase 4 (CDK4) is amplified in > 90% of de-differentiated liposarcomas (DDLS). We previously demonstrated that treatment with the CDK4 inhibitor palb...
Aggregate formation and surface activity of partially deacetylated water-soluble chitin
Water-soluble chitin (WSC), partially acetylated, was prepared by using N-acetylation in mild conditions. The aggregation behavior of WSC in aqueous solution was investigated. the results showed that… Expand