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The herpes simplex virus type 1 (HSV-1) alkaline nuclease, encoded by the UL12 gene, plays an important role in HSV-1 replication, as a UL12 null mutant displays a severe growth defect. The HSV-1 alkaline exonuclease UL12 interacts with the viral single-stranded DNA binding protein ICP8 and promotes strand exchange in vitro in conjunction with ICP8. We(More)
The single-system approach is no longer sufficient to handle the load on popular Internet servers, especially for those offering extensive multimedia content. Such services have to be replicated to enhance their availability, performance, and reliability. In a highly replicated and available environment, server selection is an important issue. In this(More)
OBJECTIVE To evaluate the prognostic factors and treatment methods of 153 uterine sarcomas. METHODS 153 cases of the uterine sarcoma were eligible for this retrospective study. Of the 153 cases, 48 were leiomyosarcomas, 47 mixed mesodermal sarcomas, 37 endometrial stromal sarcomas, 8 carcinosarcomas, 4 sarcoma botryoides, 1 fibrosarcoma, and 8 malignant(More)
Elevated levels of B cell-activating factor of the TNF family (BlyS) have been implicated in the pathogenesis of autoimmune diseases in human. Removal of pathogenic B lymphocytes by decoy receptors has demonstrated clinical benefit in both oncological and immunological diseases. In this report, we have constructed vectors for the convenient and rapid(More)
OBJECTIVE To explore the practical value of surgical-pathological staging for endometrial carcinoma. METHODS Ninety-six patients with endometrial carcinoma accepted primary surgical treatment from January 1995 to December 1999 were analyzed retrospectively in our hospital. The clinical and surgical pathologic staging of these patients were compared. (More)
This article presents a novel evaluation system along with methods to evaluate bilateral coordination of arm function on activities of daily living tasks before and after robot-assisted therapy. An affordable bilateral assessment system (BiAS) consisting of two mini-passive measuring units modeled as three degree of freedom robots is described. The process(More)
New, lower-cost tests that target high-risk human papillomavirus (HR-HPV) have been developed for cervical cancer screening in lower-resource settings but large, population-based screening studies are lacking. Women ages 25 to 65 years and living in rural China (n = 7,543) self-collected a cervicovaginal specimen, had 2 cervical specimens collected by a(More)
Functional Magnetic Resonance Imaging (fMRI) is a non-invasive technique for studying the brain activity. The data acquisition process results a temporal sequence of 3D brain images. Due to the high sensitivity of MR scanners, spikes are commonly observed in the data. Along with the temporal and spatial features of fMRI data, this artifact raises a(More)
Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus that replicates in the nucleus of its human host cell and is known to interact with many cellular DNA repair proteins. In this study, we examined the role of cellular mismatch repair (MMR) proteins in the virus life cycle. Both MSH2 and MLH1 are required for efficient replication of HSV-1 in(More)
Quantum tunneling between two plasmonic resonators links nonlinear quantum optics with terahertz nanoelectronics. We describe the direct observation of and control over quantum plasmon resonances at length scales in the range 0.4 to 1.3 nanometers across molecular tunnel junctions made of two plasmonic resonators bridged by self-assembled monolayers (SAMs).(More)