Pille Bunnell

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One of the fundamental notions offered by Humberto Maturana is that of the ontology of observing, in which the notion of (objectivity), or objectivity-in-parentheses is presented. This, in my view is not a singular notion, rather it is a matrix of coherent ideas that he often presents in a figure (Fig. 1) that he himself considers the equivalent, in the(More)
A series of Mannich bases and aminomethyl derivatives of ethyl [2,3-dichloro-4-(4-hydroxybenzoyl)phenoxy]acetate were synthesized and tested for saluretic and diuretic activities. The effects of nitrogen and aromatic nuclear substitution, reorientation of the aminomethyl group relative to that of the phenolic hydroxyl group, and replacement of either the(More)
Malnutrition in veterinary patients is thought to increase morbidity and mortality, but this has not been statistically quantified. A study was designed to estimate the proportion of hospitalized canine patients in negative-energy balance; relate calories consumed in-hospital to appetite at home shortly after discharge; determine why these dogs were in a(More)
The pivotal role of thrombosis in unstable angina and non-Q-wave myocardial infarction has been established recently. To assess the value and safety of thrombolytic therapy compared to conventional antithrombotic therapy (aspirin) in arresting progression in this setting to recurrent ischemic end-points, 25 patients presenting with unstable angina and an(More)
The pathophysiology and optimal therapy of patients who develop unstable angina in spite of long-term aspirin intake ("aspirin failure") have not been well defined. As part of a prospective study of thrombolytic therapy, 19 consecutive patients were identified who were admitted with unstable angina despite long-term aspirin therapy, and they were compared(More)
Ring annelation of the [(aminomethyl)aryloxy]acetic acids produced a series of substituted 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acids. Pharmacologic evaluation of these compounds in rats and dogs indicated that several congeners are extremely potent salidiuretics. Clearance and micropuncture experiments in rats for compound 5a confirmed the(More)
A series of substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazoles was prepared and evaluated for their saluretic and uricosuric properties. Pharmacological evaluation of the title compounds was carried out in mice, rats, dogs, and monkeys. The diuretic/saluretic nature of these compounds was observed in all species, whereas the uricosuric activity was best(More)