Pietro Palatini

Learn More
Adrenomedullin (AM) is a multifunctional peptide endowed with various biological actions mediated by the interaction with the calcitonin receptor-like receptor (CLR), which couples to the receptor activity-modifying proteins 2 or 3 (RAMP2 or RAMP3) to form the functional plasma membrane receptors AM1 and AM2, respectively. In this study, we investigated for(More)
Although the induction of cytochrome P450 (CYP) has long been investigated in patients with cirrhosis, the question whether liver dysfunction impairs the response to CYP inducers still remains unresolved. Moreover, the mechanism underlying the possible effect of cirrhosis on induction has not been investigated. Since ethical constraints do not permit(More)
  • P Palatini
  • 1988
1. A theoretical analysis has been made of the mechanism of anion activation of dopamine beta-hydroxylase on the basis of accumulated experimental data. A model is presented that accounts for the numerous different effects of activating anions on the enzyme kinetics. This model has a general validity, since it holds for any of the kinetic mechanisms thus(More)
  • 1