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Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis
One of them, circ-ZNF609, resulted in specifically controlling myoblast proliferation and is associated with heavy polysomes, providing an example of a protein-coding circRNA in eukaryotes. Expand
MicroRNA profiling in human medulloblastoma
Specific microRNA expression patterns which distinguish medulloblastoma differing in histotypes, in molecular features and in disease‐risk stratification are identified, and misregulated microRNAs expression profiles characterize human medullOBlastomas, and may provide potential targets for novel therapeutic strategies. Expand
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
Whereas miRNA expression is downregulated in cerebellar neuronal progenitors, it increases alongside differentiation, thereby allowing cell maturation and growth inhibition, and it is suggested that misregulation of specific miRNAs, leading to its aberrant activation, sustain cancer development. Expand
Purification, Cloning, and Characterization of XendoU, a Novel Endoribonuclease Involved in Processing of Intron-encoded Small Nucleolar RNAs in Xenopus laevis *
Here we report the purification, fromXenopus laevis oocyte nuclear extracts, of a new endoribonuclease, XendoU, that is involved in the processing of the intron-encoded box C/D U16 small nucleolarExpand
The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication
The conserved structural determinants of this site may provide a framework for attempting to design antiviral drugs to interfere with the infectious nidovirus life cycle. Expand
A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation
It is demonstrated that the concerted action of the master transcriptional factors RE1-silencing transcription factor (REST) and cAMP-response element binding protein (CREB) on miR-9-2 promoter induces miRNA expression during differentiation, and a regulatory feed-back mechanism, in which the reciprocal action of mi-9 and REST may be relevant for the maintenance of the neuronal differentiation program, is shown. Expand
Functional Characterization of XendoU, the Endoribonuclease Involved in Small Nucleolar RNA Biosynthesis*
The amino acid residues directly involved in XendoU catalysis are found to be essential for RNA cleavage, which occurs in the presence of manganese ions. Expand
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
It is demonstrated that FUS regulates circRNA biogenesis by binding the introns flanking the back-splicing junctions and that this control can be reproduced with artificial constructs. Expand
The Tumor Marker Human Placental Protein 11 Is an Endoribonuclease*
It is shown that the bacterially expressed human PP11 displays RNA binding capability and cleaves single stranded RNA in a Mn2+-dependent manner at uridylates, to produce molecules with 2′,3′-cyclic phosphate ends. Expand
The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells
This work identifies a crucial role for three neuronal miRNAs (9, 125a, and 125b) in controlling human neuroblastoma cell proliferation and shows that these molecules act in an additive manner by repressing a common target, the truncated isoform of the neurotrophin receptor tropomyosin-related kinase C. Expand