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BACKGROUND Intrauterine insemination with controlled ovarian hyperstimulation is commonly used as first-line treatment for couples with unexplained subfertility. Since such treatment increases the risk of multiple pregnancy, a couple's chances of achieving an ongoing pregnancy without it should be considered to identify those most likely to benefit from(More)
BACKGROUND Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. METHODS We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively(More)
OBJECTIVE To assess the accuracy of our recently developed prediction model in a prospective validation study to predict the outcome of intrauterine insemination (IUI). DESIGN Descriptive prospective validation study. SETTING Seven fertility centers in the Netherlands. PATIENT(S) Couples treated with IUI of whom the female partner had a regular cycle.(More)
BACKGROUND Prediction models have been developed in reproductive medicine to help assess the chances of a treatment-(in)dependent pregnancy. Careful evaluation is needed before these models can be implemented in clinical practice. METHODS We systematically searched the literature for papers reporting prediction models in reproductive medicine for three(More)
OBJECTIVE To evaluate the associations between the results of the male partner's semen analysis (classified according to the World Health Organization [WHO] criteria) and fathering a child without any treatment. DESIGN Prospective multicenter cohort study. SETTING Twenty subfertility centers in The Netherlands. PATIENT(S) A total of 3,345 consecutive(More)
The aim of this retrospective study was to assess the results of intrauterine insemination (IUI) in The Netherlands, using data from 2003 taken from hospital annual reports and reports from individual gynaecologists. By extrapolation, the total number of IUI cycles performed that year nationwide, and the related outcomes, was estimated. IUI was performed in(More)
OBJECTIVE To develop a prognostic model for the outcome of IUI. DESIGN Retrospective cohort study. SETTING Four fertility centers in The Netherlands. PATIENT(S) Couples of whom the female partners had a regular cycle and who had been treated with IUI. INTERVENTION(S) Intrauterine insemination with and without ovarian hyperstimulation. MAIN OUTCOME(More)
OBJECTIVE To assess the effectiveness of controlled ovarian hyperstimulation (COH) in intrauterine insemination (IUI) for subfertile couples with an abnormal postcoital test and a poor prognosis. DESIGN Randomized clinical trial. SETTING Twenty-four fertility centers in the Netherlands. PATIENT(S) Subfertile couples with a well-timed nonprogressive(More)
OBJECTIVE To assess whether pregnancy history can predict the occurrence of a spontaneous ongoing pregnancy in subfertile couples. DESIGN Prospective cohort study. SETTING Thirty fertility centers in the Netherlands. PATIENT(S) Subfertile, ovulatory women with at least one patent tube and male partners without severely impaired semen quality. (More)
After randomization of subfertile couples with an isolated cervical factor to intrauterine insemination for 6 months or expectant management for 6 months, 26 women (51%) vs. 16 women (33%) conceived, respectively. Of these pregnancies, 22 (43%) vs. 13 (27%) were ongoing (relative risk, 1.6; 95% confidence interval, 0.91 to 2.8). There was one multiple(More)