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BACKGROUND Intrauterine insemination with controlled ovarian hyperstimulation is commonly used as first-line treatment for couples with unexplained subfertility. Since such treatment increases the risk of multiple pregnancy, a couple's chances of achieving an ongoing pregnancy without it should be considered to identify those most likely to benefit from(More)
BACKGROUND Prediction models have been developed in reproductive medicine to help assess the chances of a treatment-(in)dependent pregnancy. Careful evaluation is needed before these models can be implemented in clinical practice. METHODS We systematically searched the literature for papers reporting prediction models in reproductive medicine for three(More)
BACKGROUND Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. METHODS We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively(More)
BACKGROUND Prediction models for spontaneous pregnancy may be useful tools to select subfertile couples that have good fertility prospects and should therefore be counselled for expectant management. We assessed the accuracy of a recently published prediction model for spontaneous pregnancy in a large prospective validation study. METHODS In 38 centres,(More)
OBJECTIVE To assess the accuracy of our recently developed prediction model in a prospective validation study to predict the outcome of intrauterine insemination (IUI). DESIGN Descriptive prospective validation study. SETTING Seven fertility centers in the Netherlands. PATIENT(S) Couples treated with IUI of whom the female partner had a regular cycle.(More)
OBJECTIVE To evaluate the associations between the results of the male partner's semen analysis (classified according to the World Health Organization [WHO] criteria) and fathering a child without any treatment. DESIGN Prospective multicenter cohort study. SETTING Twenty subfertility centers in The Netherlands. PATIENT(S) A total of 3,345 consecutive(More)
The aim of this retrospective study was to assess the results of intrauterine insemination (IUI) in The Netherlands, using data from 2003 taken from hospital annual reports and reports from individual gynaecologists. By extrapolation, the total number of IUI cycles performed that year nationwide, and the related outcomes, was estimated. IUI was performed in(More)
OBJECTIVE To develop a prognostic model for the outcome of IUI. DESIGN Retrospective cohort study. SETTING Four fertility centers in The Netherlands. PATIENT(S) Couples of whom the female partners had a regular cycle and who had been treated with IUI. INTERVENTION(S) Intrauterine insemination with and without ovarian hyperstimulation. MAIN OUTCOME(More)
CONTEXT Basal FSH is a marker for ovarian reserve. OBJECTIVES The objective of the study was to investigate the predictive value of basal FSH on spontaneous ongoing pregnancy in subfertile ovulatory women. DESIGN This was a prospective cohort study. SETTING The study was conducted in 19 fertility centers in The Netherlands. PARTICIPANTS Subfertile(More)
OBJECTIVE To assess the effectiveness of controlled ovarian hyperstimulation (COH) in intrauterine insemination (IUI) for subfertile couples with an abnormal postcoital test and a poor prognosis. DESIGN Randomized clinical trial. SETTING Twenty-four fertility centers in the Netherlands. PATIENT(S) Subfertile couples with a well-timed nonprogressive(More)