Pieter H. J. Bullens

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Reflex sympathetic dystrophy (RSD) is a neuropathic pain condition most often occurring in relation to trauma to, or surgery on, an extremity. It is characterized among other things by motor disturbances such as joint stiffness and tremor. Signs and symptoms can be induced in a rat model through chronic constriction of a sciatic nerve (CCI-model). In this(More)
Longevity of mated and virgin Drosophila melanogaster flies was observed at various gravity levels (1-7.38 g). A slight longevity decrease was observed in the 1-5.14 g range for virgin males, and a larger one in the 5.14-7.38 g range. The effect of gravity was larger for females in the 1-5.14 g range, and at the highest gravity level, both sexes had roughly(More)
1. Drosophila melanogaster flies have been used in studies of the effect of hypergravity (HG) on aging and longevity. 2. There is no clear longevity decrease with the gravity level up to 4 g and, even at 7 g, flies still live for roughly 40 days. 3. The HG-related changes in fecundity suggest that flies counteract an increased metabolic demand. 4. Viability(More)
Loose ligation of a rat sciatic nerve (chronic constriction injury (CCI) model) provokes signs and symptoms like those observed in reflex sympathetic dystrophy (RSD) patients. Primary afferent nociceptive C-fibers seem to be involved in an afferent orthodromic as well as in an efferent antidromic manner. In this study we hypothesize that consequent to(More)
Drosophila melanogaster flies were exposed to hypergravity starting at two days of age, the range of gravity levels used being 2.58-7.38 g. No longevity change was observed for exposures of less than 14 days. The longevity of males increased if they were submitted to hypergravity for durations ranging from 14 to 24 days. This increase in longevity was never(More)
Loose ligation of a sciatic nerve in rats (chronic constriction injury; CCI) provokes sensory, autonomic, and motor disturbances like those observed in humans with partial peripheral nerve injury. So far, it is unknown whether these motor disturbances result from (mechanical) allodynia or from damage to the motor neuron. These considerations prompted us to(More)
The life span of samples of the Oregon-R strain of Drosophila melanogaster was observed, every fourth week, during a four-year period. Large variations, most probably non-random, were observed at both 25 and 21 degrees C. The possible causes of these variations have been searched for, yet no definite conclusion can be reached. The implications of these(More)
Large diaphyseal bone defects often are reconstructed with large structural allografts but these are prone to major complications. We therefore asked whether impacted morselized bone graft could be an alternative for a massive structural graft in reconstructing large diaphyseal bone defects. Defects in the femora of goats were reconstructed using a cage(More)
The life-span of Drosophila melanogaster males kept for their entire life in atmospheres of differing O2 concentration (21%, 30%, 40%) was measured. The life-span decreased linearly with the increase in O2 proportion. In order to test the rate of living and the threshold theories of ageing, Drosophila melanogaster males were kept for 15 days in a given(More)
Reconstructions of large segmental bone defects after resection of bone tumours with massive structural allografts have a high number of reported complications including fracture, infection and non-union. Our goal is to report the survival and complications of massive allografts in our patients. A total of 32 patients were evaluated for fracture, infection,(More)