Pieter Demmers

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Inflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility. Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response. This study investigates the role that selected single nucleotide polymorphisms (SNPs) and(More)
BACKGROUND The nucleotide-binding oligomerization domain containing 1 (NOD1) gene encodes a pattern recognition receptor that senses pathogens, leading to downstream responses characteristic of innate immunity. We investigated the role of NOD1 single nucleotide polymorphisms (SNPs) on IBD risk in a New Zealand Caucasian population, and studied Nod1(More)
Background: The IBD5 (MIM# 606348) chromosomal region on 5q31 contains the genes for organic cation transporters, OCTN1 and OCTN2, and has been associated with susceptibility to adult onset CD. While several studies argue that OCTN1 and OCTN2 are the causal genes, others fail to replicate these results. participants were genotyped for functional SNPs in(More)
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