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  • Alfred H. Schinkel, Jaap Jan J. Smit, Olaf van Tellingen, Jos H. Beijnen, Piet Borst
  • Medicine, Biology
  • Cell
  • 1994 (First Publication: 1 May 1994)
  • We have generated mice homozygous for a disruption of the mdr1a (also called mdr3) gene, encoding a drug-transporting P-glycoprotein. The mice were viable and fertile and appeared phenotypicallyExpand
  • Raymond Evers, Mirjam Kool, +8 authors Piet Borst
  • Medicine, Biology
  • The Journal of clinical investigation
  • 1998 (First Publication: 1 April 1998)
  • The canalicular (apical) membrane of the hepatocyte contains an ATP-dependent transport system for organic anions, known as the multispecific organic anion transporter (cMOAT). The deduced amino acidExpand
  • Glen Reid, Peter Wielinga, +5 authors Piet Borst
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2003 (First Publication: 30 June 2003)
  • Prostaglandins are involved in a wide variety of physiological and pathophysiological processes, but the mechanism of prostaglandin release from cells is not completely understood. Although poorlyExpand
  • Jaap Jan J. Smit, Alfred H. Schinkel, Ronald P.J. Oude Elferink, Albert K. Groen, Piet Borst
  • Medicine, Biology
  • Cell
  • 1993 (First Publication: 1 November 1993)
  • Two types of P-glycoprotein have been found in mammals: the drug-transporting P-glycoproteins and a second type, unable to transport hydrophobic anticancer drugs. The latter is encoded by the humanExpand
  • Alfred H. Schinkel, Erin Wagenaar, L van Deemter, C A Mol, Piet Borst
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1995 (First Publication: 1 October 1995)
  • We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a profound effect on the tissue distribution and elimination ofExpand