Pierugo Carbonin

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OBJECTIVE To study the incidence and the risk factors of adverse drug reactions. DESIGN Multicenter survey. SETTING Hospitalized care: 22 internal medicine and 19 geriatric wards. PATIENTS All patients (n = 9,148) consecutively admitted during two observation periods of 2 months. MAIN OUTCOME MEASURE Incidence of adverse drug reactions. RESULTS(More)
PURPOSE Cognitive impairment is an exceedingly prevalent condition among patients with heart failure, independently associated with disability and mortality. However, the determinants of cognitive dysfunction associated with heart failure are still unclear. We assessed the correlates of cognitive impairment among patients with heart failure enrolled in a(More)
OBJECTIVE To evaluate the impact of a programme of integrated social and medical care among frail elderly people living in the community. DESIGN Randomised study with 1 year follow up. SETTING Town in northern Italy (Rovereto). SUBJECTS 200 older people already receiving conventional community care services. INTERVENTION Random allocation to an(More)
In order to characterize the neuropsychologic profile of patients with hypoxic-hypercapnic chronic obstructive pulmonary disease (COPD), the performance of 36 patients with COPD 69 +/- 10 yr of age (mean +/- SD) on 19 tests exploring eight cognitive domains was compared with those of 29 normal adults (69 +/- 7 yr of age), 20 normal elderly adults (78 +/- 2(More)
Calcium channel blockers can block calcium signals that trigger cell differentiation and apoptosis, which are important mechanisms of cancer growth regulation. To ascertain whether calcium channel blocker use was associated with an increased risk of cancer, 750 hypertensive persons age > or = 71 years, with no history of cancer at baseline, were followed(More)
OBJECTIVE To determine whether older persons with hypertension who use specific calcium antagonists and ACE inhibitors have a different risk of mortality than those using beta-blockers. DESIGN A prospective cohort study continuing from 1988 through 1992. SETTING Three communities of the Established Populations for Epidemiologic Studies of the Elderly.(More)
Objective. To determine the prevalence of inappropriate medication use among hospitalized older adults and to identify predictors of this use. Methods. A total of 5734 patients (mean age 79 years) admitted to geriatric and internal medicine wards participating in the study in 1995 and 1997 were included in this analysis. Inappropriate medication use was(More)
BACKGROUND Body mass index (weight in kilograms divided by the square of the height in meters [BMI]) is known to be associated with overall mortality. However, the effect of age on excess mortality from all causes associated with obesity is controversial. The aim of the present study is to determine the effect of age on the relationship between BMI and(More)
A multicenter, double-blind, randomized, placebo-controlled trial was conducted to assess the effects of verapamil on total mortality, cardiac mortality, reinfarction, and angina after an acute myocardial infarction. All patients, aged 30 to 75 years, consecutively admitted for acute myocardial infarction between 1985 and 1987 to the participating centers,(More)