Pierre R Lefèbvre

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In a randomised, placebo-controlled, double-blind study, 822 obese patients of both sexes were given either dexfenfluramine (dF), 15 mg twice daily (404), or placebo (418) in addition to a calorie-restricted diet for 1 year. Patients in both groups lost weight significantly in the first 6 months; after 6 months dF patients had a higher cumulative mean(More)
We report the clinical and radiologic features of a 31-year-old woman who suffered incongruous binasal and bitemporal visual field defects and severe sudden visual loss due to hypoperfusion of bilateral lateral geniculate bodies following anaphylactic shock induced by 500 mg amoxicillin per os. Complete neuroophthalmologic examinations were performed(More)
BACKGROUND First-line therapy for primary open-angle glaucoma and ocular hypertension generally involves prostaglandin analogue therapy. The relative efficacy of differing prostaglandin therapy is disputed. METHODS A meta-analysis was conducted of head-to-head randomized trials of prostaglandin therapies. We included randomized trials assessing(More)
Diabetes is one of the main causes of death in most developed countries. Both types of diabetes are spreading across the globe at an alarming rate, driving the condition to become one of the most challenging health problems of the 21st Century. Prevention is essential, and promoting a healthy lifestyle, early screening and investment in national programmes(More)
PURPOSE To report a case of multiple delayed recurrence of acute retinal necrosis syndrome occurring in the same eye following initial herpetic encephalitis. METHODS Case report and review of literature. RESULTS An otherwise healthy 67-year-old woman experienced three episodes of acute retinal necrosis in the left eye 3 months, 3 years, and 12 years,(More)
Riluzole is a novel neuroprotective agent that has been developed for the treatment of amyotrophic lateral sclerosis. A series of studies was undertaken to establish its pharmacokinetics on single- and multiple-dose administration in young white male volunteers. The mean absolute oral bioavailability of riluzole (50-mg tablet) was approximately 60%. Maximum(More)