Pierre Morin

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The modification of cell surface lipids or proteins with sialic acid is essential for many biological processes and several diseases are caused by defective sialic acid metabolism. Sialic acids cleaved off from degraded sialoglycoconjugates are exported from lysosomes by a membrane transporter, named sialin, which is defective in two allelic inherited(More)
We report, for the first time, high performance Ultra-thin Body and Box (UTBB) FDSOI devices with a gate length (L<sub>G</sub>) of 20nm and BOX thickness (T<sub>BOX</sub>) of 25nm, featuring dual channel FETs (Si channel NFET and compressively strained SiGe channel PFET). Competitive effective current (I<sub>eff</sub>) reaches 630&#x03BC;A/&#x03BC;m and(More)
The effect of cream pasteurization on the composition and microstructure of buttermilk after pasteurization, evaporation and spray­ drying was studied. The composition of milk fat globule membrane (MFGM) isolated from buttermilk samples was also characterized. Pasteurization of cream resulted in higher lipid recovery in the buttermilk. Spray-drying of(More)
In this paper, we examine the stock market reaction to industrial disasters. We consider an original sample of 64 explosions in chemical plants and refineries worldwide over the period 1990-2005. A quarter of the accidents resulted in a toxic release, and half of them caused at least one death or serious injury. On average, petrochemical firms in our sample(More)
A 65nm CMOS platform employing General Purpose (GP) and Low Power (LP) devices and 0.5 /spl mu/m/sup 2/ 6T-SRAM bit-cells was developed using both conventional design and low cost CMOS process flow incorporating a strained silicon solution. Fully working 0.5 /spl mu/m/sup 2/ bit-cells with 240mV of SNM and 35 /spl mu/A of cell current at 1.2V operation were(More)
For improving sensitivity of nuclear magnetic resonance (NMR) measurements, an in-field preamplifier in a low-cost CMOS process is presented. It is based on a second-generation positive current conveyor (CCII+), with an impedance-matching output stage. The circuit has been designed with optimization of key performances, such as bandwidth, noise, and offset(More)
LIM kinases 1 and 2 (LIMK1/2) are centrally positioned regulators of actin cytoskeleton dynamics. Using siRNA-mediated knockdown or a novel small molecule inhibitor, we show LIMK is required for path generation by leading tumor cells and nontumor stromal cells during collective tumor cell invasion. LIMK inhibition lowers cofilin phosphorylation, F-actin(More)
Transcription of the murine interferon-A4 (IFN-A4) gene is mediated by a virus responsive element (VRE-A4) located in the promoter proximal [-120 to -43] region. VRE-A4 contains four DNA modules (A to D) which cooperate for maximal IFN-A4 activation following virus infection. The differential expression between the highly expressed IFN-A4 and the weakly(More)
This work highlights a 65 nm CMOS technology platform for low power and general-purpose applications. A 6-T SRAM cell size of 0.69 /spl mu/m/sup 2/ with a 45 nm gate length is demonstrated. Electrical data of functional SRAM bit-cell is presented at V/sub dd/=0.9 Volt using a conventional nitrided gate oxide dielectric. A comparison between offset spacer(More)
A complete 65nm CMOS platform, called LP/GP mix, has been developed employing thick oxide transistor (1.0), low power (LP) and general purpose (GP) devices on the same chip. Dedicated to wireless multi-media and consumer applications, this new triple gate oxide platform is low cost (+mask only) and saves over 35% of dynamic power with the use of the low(More)