Pierre Moretti

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Up to 2.8 × 107 fibroblast-like cells displaying an abundant presence of mesenchymal stem cell (MSC) markers CD73, CD90, CD105 and a low level of HLA-I expression can be isolated from one whole human umbilical cord (UC) using a simple and highly reproducible explant culture approach. Cells derived from whole UC, similar to cells collected from separate(More)
Mesenchymal stem or stromal cells (MSCs) have a high potential for cell-based therapies as well as for tissue engineering applications. Since Friedenstein first isolated stem or precursor cells from the human bone marrow (BM) stroma that were capable of osteogenesis, BM is currently the most common source for MSCs. However, BM presents several(More)
A variety of cell types can be identified in the adherent fraction of bone marrow mononuclear cells including more primitive and embryonic-like stem cells, mesenchymal stem cells (MSC), lineage-committed progenitors as well as mature cells such as osteoblasts and fibroblasts. Different methods are described for the isolation of single bone marrow stem cell(More)
First isolated from bone marrow, mesenchymal stem or stromal cells (MSC) were shown to be present in several postnatal and extraembryonic tissues as well as in a large variety of fetal tissues (e.g., fatty tissue, dental pulp, placenta, umbilical cord blood, and tissue). In this study, an optimized protocol for the expansion of MSC-like cells from whole(More)
Leukemia inhibitory factor (LIF) is a polyfunctional cytokine with numerous regulatory effects in vivo and in vitro. In stem cell cultures it is the essential media supplement for the maintenance of pluripotency of embryonic and induced pluripotent stem cells. With regard to large scale cultures of these cells, LIF is needed in high quality and quantity and(More)
Galway, Ireland Subpopulations in Mesenchymal Stem Cell-Like Cultures from Human Umbilical Cord: Identification and Characterization Tim Hatlapatka, Ingrida Majore, Pierre Moretti, Ralf Hass, Cornelia Kasper Corresponding Author: kasper@iftc.uni-hannover.de Leibniz University of Hannover, Institute of Technical Chemistry, Callinstraße 5, D-30167 Hannover(More)
Galway, Ireland Investigation of the Osteogenic Potential of Mesenchymal Stromal Cells derived from Human Umbilical Cord Tissue Pierre Moretti, Stefanie Boehm, Antonina Lavrentieva, Tim Hatlapatka, Ralf Hass, Thomas Scheper, Cornelia Kasper Corresponding Author: Kasper @iftc.uni-hannover.de 1 Institute of Technical Chemistry, University of Hannover,(More)
Heart and vascular endothelial cells from human pluripotent stem cells are of interest for applications in cell therapy and cardiovascular disease. Differentiation protocols are now sufficiently refined that production of cardiomyocytes, endothelialand smooth muscle cells is fairly efficient and reproducible. Genetically marked hESCs have been produced in(More)
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