Pierre Goussard

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Dihydropteroate synthase (DHPS) gene mutations have raised concerns about emerging sulfonamide resistance in Pneumocystis jirovecii. DHPS and dihydrofolate reductase (DHFR) gene products were amplified in clinical specimens from South African patients. One of 53 DHPS genes sequenced contained the double mutation Thr55Ala Pro57Ser. DHFR gene mutations(More)
986 Airway involvement is relatively commonly seen in children with primary tuberculosis (TB), but in only a small group of children is the compression severe, needing intervention. The incidence of children with airway obstruction due to primary TB in the chemotherapeutic era is not known. In two recent reports the incidence of complicated lymph node(More)
Foreign bodies are potentially life-threatening when inhaled by a child, depending on where they lodge. Symptoms can range from acute upper airway obstruction to mild, vague respiratory complaints. Between 80% and 90% of inhaled foreign bodies occlude the bronchi, while the larynx is a less common site. The commonest inhaled paediatric foreign bodies are(More)
Airway deformation and stenosis can be key signs of pathology such as lymphadenopathy. This study presents a local airway point distribution model (LA-PDM) to automatically analyse regions of the airway tree in CT scans and identify abnormal airway deformation. In our method, the airway tree is segmented and the centreline identified from each chest CT(More)
Clinical signs of paediatric pulmonary tuberculosis (TB) include stenosis and deformation of the airways. This paper presents two methods to analyse airway shape and detect airway pathology from CT images. Features were extracted using (1) the principal components of the airway surface mesh and (2) branch radius and orientation features. These methods were(More)
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