Pierre-François D'Haese

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Non-rigid registration algorithms have been proposed over the years to register medical images to each other. One class of applications for these algorithms is the automatic segmentation of structures and substructures using a predefined atlas. But these algorithms have been limited to image volumes without gross abnormalities or pathologies and have thus(More)
In current practice, optimal placement of deep-brain stimulators (DBSs) used to treat movement disorders in patients with Parkinson's disease and essential tremor is an iterative procedure. A target is chosen preoperatively based on anatomical landmarks identified on magnetic resonance images. This point is used as an initial position that is refined(More)
This paper presents a fully automated brain segmentation method that has been applied to a group of patients with infratento-rial ependymoma. The purpose of the study was to test the hypothesis that fully-automated atlas-based segmentation methods provide useful normal tissue dosimetry from which dose-volume modeling may be performed in a manner equivalent(More)
In this paper we study and evaluate the influence of the choice of a particular reference volume as the electrophysiological atlas on the accuracy of the automatic predictions of optimal points for deep brain stimulator (DBS) implants. We refer to an electrophysiological atlas as a spatial map of electrophysiological information such as micro electrode(More)
A number of methods have been developed to assist surgeons at various stages of deep brain stimulation (DBS) therapy. These include construction of anatomical atlases, functional databases, and electrophysiological atlases and maps. But, a complete system that can be integrated into the clinical workflow has not been developed. In this paper we present a(More)
PURPOSE In the recent past many groups have tried to build functional atlases of the deep brain using intra-operatively acquired information such as stimulation responses or micro-electrode recordings. An underlying assumption in building such atlases is that anatomical structures do not move between pre-operative imaging and intra-operative recording. In(More)
BACKGROUND This study reports the intersurgeon variability in manual selection of the anterior and posterior commissures (AC and PC). The study also investigates the effect of this variability on the localization of targets like the subthalamic nucleus, ventralis intermedius nucleus and globus pallidus internus. The additional effect of variation in the(More)
INTRODUCTION Postoperative programming in deep brain stimulation (DBS) therapy for movement disorders can be challenging and time consuming. Providing the neurologist with tools to visualize the electrode location relative to the patient's anatomy along with models of tissue activation and statistical data can therefore be very helpful. In this study, we(More)
The anterior and posterior commissures (AC and PC) typically form the reference points of the stereotactic coordinate system. Hence any discussion of target localization is limited by the variability of AC and PC selection. In an earlier study, which was performed using manual selections of AC and PC by 43 neurosurgeons, we showed that intersurgeon(More)