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OBJECTIVE The purpose of the study was to investigate sound localization with bilateral and unilateral cochlear implants. DESIGN Sound localization tests were performed on 20 bilaterally implanted MED-EL COMBI 40/40+ users. All subjects were bilaterally implanted during adolescence or later. Sound localization was tested in the frontal horizontal plane by(More)
OBJECTIVE The aim of the study was to investigate the impact of bilateral cochlear implant use on speech perception in noise in bilateral users of the MED-EL COMBI 40/40+ cochlear implants. DESIGN Speech reception thresholds were measured in 21 subjects using the Oldenburg sentence test. Speech was always presented from the front. Noise was either(More)
In current practice, optimal placement of deep-brain stimulators (DBSs) used to treat movement disorders in patients with Parkinson's disease and essential tremor is an iterative procedure. A target is chosen preoperatively based on anatomical landmarks identified on magnetic resonance images. This point is used as an initial position that is refined(More)
BACKGROUND This study reports the intersurgeon variability in manual selection of the anterior and posterior commissures (AC and PC). The study also investigates the effect of this variability on the localization of targets like the subthalamic nucleus, ventralis intermedius nucleus and globus pallidus internus. The additional effect of variation in the(More)
BACKGROUND Recent evidence suggests that deep brain stimulation of the subthalamic nucleus (STN-DBS) may have a disease modifying effect in early Parkinson's disease (PD). A randomised, prospective study is underway to determine whether STN-DBS in early PD is safe and tolerable. OBJECTIVES/METHODS 15 of 30 early PD patients were randomised to receive(More)
Non-rigid registration algorithms have been proposed over the years to register medical images to each other. One class of applications for these algorithms is the automatic segmentation of structures and substructures using a predefined atlas. But these algorithms have been limited to image volumes without gross abnormalities or pathologies and have thus(More)
A number of methods have been developed to assist surgeons at various stages of deep brain stimulation (DBS) therapy. These include construction of anatomical atlases, functional databases, and electrophysiological atlases and maps. But, a complete system that can be integrated into the clinical workflow has not been developed. In this paper we present a(More)
The anterior and posterior commissures (AC and PC) typically form the reference points of the stereotactic coordinate system. Hence any discussion of target localization is limited by the variability of AC and PC selection. In an earlier study, which was performed using manual selections of AC and PC by 43 neurosurgeons, we showed that intersurgeon(More)
In this paper we study and evaluate the influence of the choice of a particular reference volume as the electrophysiological atlas on the accuracy of the automatic predictions of optimal points for deep brain stimulator (DBS) implants. We refer to an electrophysiological atlas as a spatial map of electrophysiological information such as micro electrode(More)
This paper presents a fully automated brain segmentation method that has been applied to a group of patients with infratento-rial ependymoma. The purpose of the study was to test the hypothesis that fully-automated atlas-based segmentation methods provide useful normal tissue dosimetry from which dose-volume modeling may be performed in a manner equivalent(More)