Pierre Demol

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The effect of neurotensin on rat pancreatic secretion was studied in the conscious animal as well as on pancreatic lobules. In vivo neurotensin induced a dose-related inhibition of both water and protein basal secretion. Protein secretion was much more depressed than fluid secretion. Neurotensin did not modify the pancreatic response to exogenous secretin(More)
The review describes gastrointestinal receptors which are of therapeutic interest for the treatment of motility disorders. It updates the present knowledge on muscarinic, adrenergic, dopamine, opioid and dihydropyridine receptors, their subtypes, cellular sites and functional role as drug targets. On the basis of this pharmacological receptor concept, drugs(More)
Neurotensin is a brain-gut tridecapeptide. It can be released into the circulation upon ingestion of a meal, or when the jejuno-ileal segment of the human gut is exposed to a mixed meal. Among the various constituents of the products of food digestion, fatty acid is the most potent in stimulating immunoreactive neurotensin release. This response is dose(More)
T-lymphocyte subsets and human T-cell lymphotropic virus type III antibody prevalence were studied in African patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC), and in female prostitutes. African blood donors and healthy Zairian and Rwandese persons matched for age, sex, and annual income served as controls.(More)
Nervous control of gastrointestinal motility is extremely complex, is regulated by the enteric system, the “brain of the gut”, and modulated by extrinsic nerves. This system with its multiplicity of transmitters and receptors does not always allow a clear interpretation of experimental data, especially with compounds lacking specificity. In this review the(More)
On different days, fasted volunteers were given either 100 ml of ethanol (40% v/v), glucose (isocaloric to ethanol) or distilled water intragastrically; the instillations always starting during the first observed duodenal phase I of the interdigestive migrating complex (IMC). Both ethanol and glucose produced a fed pattern of motility but only glucose(More)
The effect of four different catecholamines (adrenaline, noradrenaline, isoprenaline and dopamine) were tested on the exocrine pancreatic secretion of conscious rats equipped with a pancreatic and biliary fistula, bile being continuously recirculated into the duodenum. Contrary to what has been observed in the anaesthetized animal neither of these four(More)