Pierre Brossier

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An electrochemical DNA detection method has been developed for the sensitive quantification of an amplified 406-base pair human cytomegalovirus DNA sequence (HCMV DNA). The assay relies on (i) the hybridization of the single-stranded target HCMV DNA with an oligonucleotide-modified Au nanoparticle probe, (ii) followed by the release of the gold metal atoms(More)
We describe here a new approach for multilabel immunoassays. The starting point of this approach is a new nonradioisotopic immunoassay (carbonyl metallo immunoassay) based on the use of metal carbonyl complexes as tracers and Fourier transform infrared (FT-ir) spectroscopy as the detection method. We show here that the judicious choice of the organometallic(More)
A scanning Fabry-Perot interferometer for use in the far ir (100 microm < < 2 mm) has been developed capable of scanning a free spectral range in a few milliseconds. A commercial loudspeaker was used as a drive, and mirrors were fabricated from electroformed copper mesh. Primary limitations of the instrument were due to vibrations of the interferometer(More)
Metalloimmunoassay is a new immunoassay using an organometallic complex as the label. For the development of this assay, antibodies were produced in rabbits immunized with N-succinyldesipramine-bovine serum albumin conjugate. Antisera thus obtained were shown to be specific for the tricyclic antidepressant group of drugs and are tested as regard as(More)
In order to develop a new immunoassay procedure based on the use of organometallic labels, antisera are raising against sedative-hypnotic drug: phenobarbital. Immunization was performed in rabbits with parasuccinylamidophenobarbital coupled to bovine-serum-albumin. The evaluation of the specificity and the affinity constants of antisera are studied against(More)
The Centre de Documentation Sciences Humaines (CDSH) of the Centre National de la Recherche Scientifique was soon aware of the necessity to make its data bases multilingual so as to increase the speed, extent and ease of access to the whole of this information. Parallel to other ongoing trials, an experiment with automatic translation now being conducted(More)