Pierre Andreoletti

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Opuntia ficus-indica, commonly referred to as prickly pear or nopal cactus, is a dicotyledonous angiosperm plant. It belongs to the Cactaceae family and is characterized by its remarkable adaptation to arid and semi-arid climates in tropical and subtropical regions of the globe. In the last decade, compelling evidence for the nutritional and health benefit(More)
X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and tissues of patients. Under its severe form, brain demyelination and inflammation are observed. Therefore, we determined the effects of C24:0 and C26:0 on glial(More)
We consider Sinai's random walk in random environment. We prove that for an interval of time [1, n] Sinai's walk sojourns in a small neighborhood of the point of localization for the quasi totality of this amount of time. Moreover the local time at the point of localization normalized by n converges in probability to a well defined random variable of the(More)
In some neurodegenerative disorders (leukodystrophies) characterized by myelin alterations, the defect of peroxisomal functions on myelin-producing cells (oligodendrocytes) are poorly understood. The development of in vitro models is fundamental to understanding the physiopathogenesis of these diseases. We characterized two immortalized murine(More)
Liver is a major regulator of lipid metabolism and adaptation to fasting, a process involving PPARalpha activation. We recently showed that the Vnn1 gene is a PPARalpha target gene in liver and that release of the Vanin-1 pantetheinase in serum is a biomarker of PPARalpha activation. Here we set up a screen to identify new regulators of adaptation to(More)
Among several peroxisomal neurodegenerative disorders, the pseudoneonatal adrenoleukodystrophy (P-NALD) is characterized by the acyl-coenzyme A oxidase 1 (ACOX1) deficiency, which leads to the accumulation of very-long-chain fatty acids (VLCFA) and inflammatory demyelination. However, the components of this inflammatory process in P-NALD remain elusive. In(More)
J o u r n a l o f P r o b a b i l i t y Electron. Abstract In this paper we consider a null recurrent random walk in random environment on a super-critical Galton-Watson tree. We consider the case where the log-Laplace transform ψ of the branching process satisfies ψ(1) = ψ (1) = 0 for which G. Faraud, Y. Hu and Z. Shi have shown that, with probability one,(More)
Differential regulation of peroxisome proliferator-activated receptor (PPAR)-a1 and truncated PPARa2 as an adaptive response to fasting in the control of hepatic peroxisomal fatty acid b-oxidation in the hibernating mammal Abstract: Seasonal obesity and fasting-associated hibernation are the 2 major metabolic events governing hepatic lipid metabolism in(More)