Pierangela Giustetto

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The carotid plaques characterization is essential to decide about the possibility of surgical intervention (endarterectomy/stenting) on the patient. Soft and unstable plaques represent a major risk for the patient, as they are correlated with an augmented probability of brain infarction and emboli generation. Hence, the minimally-invasive characterization(More)
Dextran nanobubbles were prepared with a dextran shell and a perfluoropentan core in which oxygen was stored. To increase the stability polyvinylpirrolidone was also added to the formulation as stabilizing agent. Rhodamine B was used as fluorescent marker to obtain fluorescent nanobubbles. The nanobubble formulations showed sizes of about 500nm, a negative(More)
The analysis of the carotid wall is of paramount importance in clinical practice. In fact, the intima-media thickness is a risk index for some of the most severe acute cerebrovascular pathologies; hence, the need for an accurate segmentation of the different layers of the carotid artery. In the past ten years, a wide variety of algorithms for the carotid(More)
Non-invasive plaque characterization of the carotid wall is crucial for the early assessment of pathology, as well as for the monitoring of the progression of a degenerative phenomenon. Specifically, in clinical practice the carotid wall status is assessed by means of B-Mode ultrasound scans. We recently implemented an algorithm for the segmentation of the(More)
Chitosan-coated oxygen microbubbles of average diameter 2.5 mum, narrow size distribution and spherical shape were prepared. A core-shell structure was evidenced by fluorescence microscopy using fluorescent microbubbles. Such microbubbles can be a therapeutic device for vehiculating oxygen to hypoxic tissues, provided they show proper permeability and(More)
Three types of cyclodextrin nanosponges were synthetized cross-linking α, β or γ cyclodextrin with carbonyldiimidazole as cross-linker. Nanosponges are solid nanoparticles previously used as drug carriers. In this studies cyclodextrin nanosponges were developed as oxygen delivery system. For this purpose the three types of nanosponges suspended in water(More)
The main goal of this study was to assess the theranostic performance of a nanomedicine able to generate MRI contrast as a response to the release from liposomes of the antitumor drug Doxorubicin triggered by the local exposure to pulsed low intensity non focused ultrasounds (pLINFU). In vitro experiments showed that Gadoteridol was an excellent imaging(More)
Thermo-responsive chitosan microbubbles were developed as new therapeutic device for vehiculating gases to tissues concomitantly to hyperthermic treatments. Aiming at applications to non-invasive temperature monitoring, microbubbles were characterized for acoustic attenuation properties in the 1-15 MHz range both by direct methods and by B-mode Ultrasound(More)
The development of nanomedicines in cancer therapy is constantly growing because of the advantages associated with the use of nanosized drug delivery systems. Among them, the possibility of accurate spatiotemporal control of the release of the chemotherapeutic from the carrier is one of the most interesting and clinically relevant. To further improve the(More)