Pier-Luc Clermont

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The p110 Cut homeobox 1 (CUX1) transcription factor regulates genes involved in DNA replication and chromosome segregation. Using a genome-wide-approach, we now demonstrate that CUX1 also modulates the constitutive expression of DNA damage response genes, including ones encoding ATM and ATR, as well as proteins involved in DNA damage-induced activation of,(More)
Overexpression of the Cut homeobox 1 gene, CUX1, inverselycorrelates with patient survival in breast cancers. Cell-based assays andmolecular studies have revealed that transcriptional regulation byCUX1 involves mostly the proteolytically processed p110isoform. As there is no antibody specific to p110 CUX1 only, an alternatestrategy must be employed to(More)
The Editor, Marc Lippman, and Associate Editors: Stephen P. Ethier, Kevin S. Hughes, Alberto Montero, Steven A. Narod, and Ben H. Park would like to acknowledge the valuable contributions of the reviewers to the journal. We fully understand the burden and effort that are involved in the reviews. We rely on your expertise to maintain the standards of(More)
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