Phyllis Goldman

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Tumor induction by 7,12-dimethylbenz[a]anthracene (DMBA) or inoculation with adenocarcinoma cells was studied in rats raised in groups (group G) or individually (group I) as well as in rats raised in groups and switched to individual housing at the beginning of the experiment (group G/I). The number of DMBA-induced tumors did not differ among the three(More)
Label-free quantitative proteomics holds a great deal of promise for the future study of both medicine and biology. However, the data generated is extremely intricate in its correlation structure, and its proper analysis is complex. There are issues with missing identifications. There are high levels of correlation between many, but not all, of the peptides(More)
The relationship between striatal dopamine-stimulated adenylate cyclase (DAC) and 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors was studied. An inverse correlation between activity of this enzyme and the number and growth of tumors was observed in several strains and substrains of rats. Chronic, but not acute, restraint stress inhibited tumor(More)
Number and development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced tumors are higher in Sprague-Dawley (SD) than Long-Evans (LE) rats and restraint retards tumor development in SD rats. Prolactin levels in LE hooded and SD rats were similar at ages 62 and 93 days whereas estradiol levels were considerably lower in the LE strain at the early age only.(More)
A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay.
The balanced translocations that occur between the c-myc and immunoglobulin loci in Burkitt lymphoma provide an unusual opportunity to analyze both products of a reciprocal recombination. Accordingly, we have determined the structure of the two reciprocal products of a translocation that joins the 5' portion of the c-myc gene on chromosome 8 to the(More)