Phuong Thao Pham

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The pathogenesis of experimental cerebral malaria (ECM) is an immunologic process, mediated in part by Th1 CD4(+) T cells. However, the role of the Th1 CD4(+) T cell differentiation program on the ability to control parasitemia and susceptibility to ECM disease during blood stage malaria has never been assessed directly. Using the Plasmodium berghei ANKA(More)
In this paper we introduce our explorative work on the concepts and taxonomy of the misunderstanding in interaction and on the architectural mechanism solving this problem in interactive systems. System actors interacting during the software execution may face misunderstandings when the internal data of at least one actor evolve differently from other ,(More)
BACKGROUND There is still a need to improve the sensitivity of polymerase chain reaction (PCR) tests for malaria to detect submicroscopic asexual stage Plasmodium infections during the early phase and chronic, asymptomatic phase of infection when the parasite burden is very low. STUDY DESIGN AND METHODS The inhibitory effect of hemoglobin (Hb) on PCR(More)
Highly sensitive and reliable assays based on the quantitation of immunologically relevant component(s) in recombinant or whole parasite-based vaccines would facilitate pre-clinical and clinical phases and the monitoring of malaria vaccine deployment. Here we report a laboratory-grade Western Blot assay for quantitative detection of Plasmodium falciparum(More)
BACKGROUND γ-irradiation is commonly used to create attenuation in Plasmodium parasites. However, there are no systematic studies on the survival, reversion of virulence, and molecular basis for γ-radiation-induced cell death in malaria parasites. METHODS The effect of γ-irradiation on the growth of asexual Plasmodium falciparum was studied in erythrocyte(More)
This paper is an overview of our work to deal with scenario representation and management model in Online Distant Learning domain. Our approach is based on scenario structuring using the notion of “situation”. A “situation” is an elementary building block dividing the interactions between actors into contextual scenes. This pattern not only supports the(More)
The games are typical interactive applications where the system has to react to user actions and behavior with respect to some predefined rules established by the designer. The storytelling allows the interactive system to unfold the scenario of the game story according to these inputs and constraints. In order to improve system’s behavior, the scenario(More)
Background Multiplex ELISA that detect antibodies against more than one Plasmodium species while allowing species differentiation would be highly valuable for epidemiology and vaccine studies in areas of mixed infections and identification of malaria-exposed blood donors in non-endemic countries. Here we report a highly sensitive, multiplex ELISA based on(More)
During interactions, system actors may face up to misunderstandings when their local visions contain inconsistent data about a same fact. Misunderstandings in interaction are likely to reduce interactivity performances (deviation or deadlock) or even affect overall system behavior. In this paper, we present agent-based architecture and scenario-structuring(More)