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The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine has recently been reported to antagonize certain overt withdrawal signs in morphine dependent rats. The purpose of the present study was to reassess this response and examine the effect of this drug in a model presumably reflective of the motivational impact of withdrawal using(More)
In the present study we have examined the interaction between the selective cholecystokinin (CCK)A and CCKB receptor antagonists, devazepide and L365-260 on morphine conditioned place preference (CPP). Using an unbiased procedure, morphine (1.5 mg/kg) produced a reliable CPP which was observed irrespective of the conditioning compartment type. Pretreatment(More)
The effect of the selective 5-HT3 receptor antagonists, ondansetron and MDL 72,222, against various behaviours elicited by naloxone-precipitated morphine withdrawal were examined. Rats made dependent upon morphine by the subcutaneous implantation of a 75 mg pellet, when challenged with naloxone (0.5 mg/kg SC), 3 or 4 days later exhibited a wide range of(More)
The purpose of the present study was to reassess the original findings of Carboni et al. (1988) who suggested that 5-HT3 receptor antagonists may block morphine-induced place conditioning in rats. These workers used a biased protocol with treatments allocated to compartments based on initial preference. In the present study we have adopted an unbiased(More)
— The specific choice of workload task schedulers for Hadoop MapReduce applications can have a dramatic effect on job workload latency. The Hadoop Fair Scheduler (FairS) assigns resources to jobs such that all jobs get, on average, an equal share of resources over time. Thus, it addresses the problem with a FIFO scheduler when short jobs have to wait for(More)
A high quality hierarchical organization of the concepts in a dataset at different levels of granularity has many valuable applications such as search, summarization, and content browsing. In this paper we propose an algorithm for recursively constructing a hierarchy of topics from a collection of content-representative documents. We characterize each topic(More)
In this paper we present a framework for forming interests-based Peer-to-Peer communities using client-side web browsing history. At the heart of this framework is the use of an order statistics-based approach to build communities with hierarchical structure. We have also carefully considered privacy concerns of the peers and adopted cryptographic protocols(More)
We define a new NP search problem, the " local improvement " principle , about labellings of an acyclic, bounded-degree graph. We show that, provably in PV, it characterizes the ∀Σ b 1 consequences of V 1 2 and that natural restrictions of it characterize the ∀Σ b 1 consequences of U 1 2 and of the bounded arithmetic hierarchy. We also show that over V 0 it(More)