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Recommender systems provide personalized suggestions about items that users will find interesting. Typically, recommender systems require a user interface that can ``intelligently'' determine the interest of a user and use this information to make suggestions. The common solution, ``explicit ratings'', where users tell the system what they think about a(More)
We are proposing an extension of the recursive neural network that makes use of a variant of the long short-term memory architecture. The extension allows information low in parse trees to be stored in a memory register (the ‘memory cell’) and used much later higher up in the parse tree. This provides a solution to the vanishing gradient problem and allows(More)
The forkhead box n1 (Foxn1) transcription factor is essential for thymic organogenesis during embryonic development; however, a functional role of Foxn1 in the postnatal thymus is less well understood. We developed Foxn1 transgenic mice (Foxn1Tg), in which overexpression of Foxn1 is driven by the human keratin-14 promoter. Expression of the Foxn1 transgene(More)
We propose the first implementation of an infinite-order generative dependency model. The model is based on a new recursive neural network architecture, the Inside-Outside Recursive Neural Network. This architecture allows information to flow not only bottom-up, as in traditional recursive neural networks, but also topdown. This is achieved by computing(More)
Despite playing a critical role in the development of naive T cells, the thymus is involuted with age. Whether a single age-associated defect or multiple aberrations contribute to thymic involution remains controversial. Here, we determined molecular aberrations in the thymocyte and epithelium compartments of the aging thymus. We demonstrated that total(More)
Signal joint T cell receptor delta (TCRD) excision circles (TRECs) are episomal DNA circles generated by the DNA recombination process that is used by T lymphocytes to produce antigen-specific alpha/beta T cell receptors. Measurement of TRECs in thymocytes and peripheral blood T cells has been used to study thymus output in chickens and humans. We have(More)
The CD44 inhibitor Lutheran [In(Lu)]-related p80 molecule has recently been shown to be identical to the Hermes-1 lymphocyte homing receptor and to the human Pgp-1 molecule. We have determined the effect of addition of CD44 antibodies to in vitro activation assays of PBMC. CD44 antibodies did not induce PBMC proliferation alone, but markedly enhanced PBMC(More)
Intestinal mucosa is constantly exposed to environmental AGS: Activation of lamina propria (LP) T cells by luminal Ags may lead to the production of inflammatory cytokines and subsequent mucosal inflammation and tissue damage. However, in normal circumstances, LP T cells do not respond to antigenic stimulation. The mechanisms of this unresponsiveness in(More)
Previously, this laboratory showed that in utero and in vitro ethanol exposure significantly reduces developing serotonin (5-HT) neurons and that treatment with a 5-HT1A agonist such as buspirone or ipsapirone prevents the ethanol-associated loss. The present study investigated whether ethanol decreases fetal rhombencephalic neurons, including 5-HT neurons,(More)