Phong Dai Thi Nguyen

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Voltage-gated Na(+) channels may play important roles in establishing pathological neuronal hyperexcitability associated with chronic pain in humans. Na(+) channel blockers, such as carbamazepine (CBZ) and lamotrigine (LTG), are efficacious in treating neuropathic pain; however, their therapeutic utility is compromised by central nervous system side(More)
Antimicrobial resistance is a major global health threat. In the European Union an estimated 25,000 deaths occur annually secondary to multi-drug-resistant infections [1]. No reliable estimates for developing countries exist, but figures are likely to be higher. Strategies to contain antimicrobial resistance were comprehensively set forth by the World(More)
RNA interference (RNAi) is an exciting new tool to effect acute in vivo knockdown of genes for pharmacological target validation. Testing the application of this technology to metabolic disease targets, three RNAi delivery methods were compared in two frequently utilized preclinical models of obesity and diabetes, the diet-induced obese (DIO) and(More)
Recommendation systems often rely on point-wise loss metrics such as the mean squared error. However, in real recommendation settings only few items are presented to a user. This observation has recently encouraged the use of rank-based metrics. LambdaMART is the state-of-the-art algorithm in learning to rank which relies on such a metric. Motivated by the(More)
Knowledge Discovery in Databases is a complex process that involves many different data processing and learning operators. Today's Knowledge Discovery Support Systems can contain several hundred operators. A major challenge is to assist the user in designing workflows which are not only valid but also – ideally – optimize some performance measure associated(More)
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