Phoebe S Leboy

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A comparisonof the transferRNA (tRNA) methyltransferases from rat mammary gland and mammary tumors was carried out to explore possible tumor-specific differences in enzyme activ ity, substrate specificity, and capacity to methylatebacterial tRNA substrates. Enzymes from 9,1 0-dimethyl-1,2-benzan thracene-induced mammary tumors had specific activities 2-to(More)
A previous study demonstrated that the incorporation of bioactive glass (BG) into poly (lactic-co-glycolic acid) (PLGA) can promote the osteoblastic differentiation of marrow stromal cells (MSCs) on PLGA by promoting the formation of a calcium-phosphate-rich layer on its surface. To further understand the mechanisms underlying the osteogenic effect of(More)
  • M P Reinhart, J M Lewis, P S Leboy
  • 1986
A tRNA (guanine-2) methyltransferase has been purified to homogeneity from the protozoan Tetrahymena pyriformis. The enzyme methylates purified E. coli tRNAs which have a guanine residue at position 26 from the 5' end; it also methylates tRNA prepared from the m22G- yeast mutant trm 1. This methyltransferase is therefore equivalent to the guanine(More)
BACKGROUND: During endochondral bone formation, the hypertrophy of chondrocytes is accompanied by selective expression of several genes including type X collagen and alkaline phosphatase. This expression is stimulated by inducers including BMPs and ascorbate. A 316 base pair region of the type X collagen (Col X) promoter has been previously characterized as(More)
It has been over 30 years since the beginning of efforts to improve diversity in academia. We can identify four major stages: (1) early and continuing efforts to diversify the pipeline by increasing numbers of women and minorities getting advanced degrees, particularly in science, technology, engineering, and math (STEM); (2) requiring academic institutions(More)
Methylation reactions carried out with mammalian transfer RNA (tRNA) methyltransferases and RNA prepared from the homologous source do not normally show significant incorporation of methyl groups into the tRNA. However, our studies with the transplantable mammary adenocarcinoma 13762 indicate that tRNA from this tumor can be methylated in vitro with the(More)
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