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The use of metabolising systems for in vitro testing of endocrine disruptors.

• Miriam N. Jacobs, Wim Janssens, +13 authors Bart van der Burg
• Current drug metabolism
• 2008

Legislation and prospective legislative proposals in for instance the USA, Europe, and Japan require, or may require that chemicals are tested for their ability to disrupt the hormonal systems of… (More)

Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity.

• L. J. Ball, Ralph Kühne, +9 authors Thomas Jarchau
• The EMBO journal
• 2000

The Ena-VASP family of proteins act as molecular adaptors linking the cytoskeletal system to signal transduction pathways. Their N-terminal EVH1 domains use groups of exposed aromatic residues to… (More)

Absorption dynamics of organic chemical transport across trout gills as related to octanol-water partition coefficient.

• James McKim, Phillip Schmieder, Gilman Veith
• Toxicology and applied pharmacology
• 1985

An in vivo fish preparation was used that allowed a direct measure of the transport rates of 14 different organic chemicals across the gills of rainbow trout (Salmo gairdneri). The chemicals, all C14… (More)

Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites.

• Michael Smalla, Phillip Schmieder, +6 authors Hartmut Oschkinat
• Protein science : a publication of the Protein…
• 1999

The sterile alpha motif (SAM) is a protein interaction domain of around 70 amino acids present predominantly in the N- and C-termini of more than 60 diverse proteins that participate in signal… (More)

A computationally based identification algorithm for estrogen receptor ligands: part 1. Predicting hERalpha binding affinity.

• Steven P. Bradbury, Verginia B Kamenska, Phillip Schmieder, Gerald T. Ankley, Ovanes Mekenyan
• Toxicological sciences : an official journal of…
• 2000

The common reactivity pattern (COREPA) approach is a 3-dimensional, quantitative structure activity relationship (3-D QSAR) technique that permits identification and quantification of specific global… (More)

Application of nonlinear sampling schemes to COSY-type spectra.

• Phillip Schmieder, Amos Stern, G. Wagner, Jeffrey Hoch
• Journal of biomolecular NMR
• 1993

Nonlinear sampling along the t1 dimension is applied to COSY-type spectra. The sine dependence of the time domain signals for the cross peaks is matched by a nonlinear sampling scheme that samples… (More)

Characterization of dansylated glutathione, glutathione disulfide, cysteine and cystine by narrow bore liquid chromatography/electrospray ionization mass spectrometry.

• Dean E. Hammermeister, J. Serrano, Phillip Schmieder, Douglas W Kuehl
• Rapid communications in mass spectrometry : RCM
• 2000

A method using reversed phase high performance liquid chromatography/electrospray ionization-mass spectrometry (RP-LC/ESI-MS) has been developed to confirm the identity of dansylated derivatives of… (More)

Improved resolution in triple-resonance spectra by nonlinear sampling in the constant-time domain.

• Phillip Schmieder, Amos Stern, G. Wagner, Jeffrey Hoch
• Journal of biomolecular NMR
• 1994

Nonlinear sampling along the constant-time dimension is applied to the constant-time HNCO spectrum of the dimerization domain of Gal4. Nonlinear sampling was used for the nitrogen dimension, while… (More)

MUSIC, selective pulses, and tuned delays: amino acid type-selective (1)H-(15)N correlations, II.

• M. Schubert, Hartmut Oschkinat, Phillip Schmieder
• Journal of magnetic resonance
• 2001

Amino acid type-selective experiments help to remove ambiguities in either manual or automated assignment procedures. Here we present modified triple-resonance experiments that yield amino acid… (More)

The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA.

• Martin Schade, C. J. Turner, +5 authors Hartmut Oschkinat
• Proceedings of the National Academy of Sciences…
• 1999

Double-stranded RNA deaminase I (ADAR1) contains the Z-DNA binding domain Zalpha. Here we report the solution structure of free Zalpha and map the interaction surface with Z-DNA, confirming roles… (More)

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