Phillip P. Salvatore

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BACKGROUND The projected long-term prevalence of multidrug-resistant (MDR) tuberculosis depends upon the relative fitness of MDR Mycobacterium tuberculosis strains, compared with non-MDR strains. While many experimental models have tested the in vitro or in vivo fitness costs of various drug resistance mutations, fewer epidemiologic studies have attempted(More)
Background Substantial individual heterogeneity exists in the clinical manifestations and duration of active tuberculosis. We sought to link the individual-level characteristics of TB disease to observed population-level outcomes. Methods We developed an individual-based, stochastic model of TB disease in a hypothetical cohort of patients with(More)
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