Phillip M. Rivera

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The behavior of gene modules in complex synthetic circuits is often unpredictable. After joining modules to create a circuit, downstream elements (such as binding sites for a regulatory protein) apply a load to upstream modules that can negatively affect circuit function. Here we devised a genetic device named a load driver that mitigates the impact of load(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract— This paper considers the problem of attenuating retroactivity, that is, the effect of loads in biological networks and demonstrates that signal transduction cascades incorporating phosphotransfer modules have remarkable(More)
— We seek to minimize both the retroactivity to the output and the retroactivity to the input of a phosphorylation-based insulation device by finding an optimal substrate concentration. Characterizing and improving the performance of insulation devices brings us a step closer to their successful implementation in biological circuits, and thus to modularity.(More)
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