Phillip M. Rivera

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— We seek to minimize both the retroactivity to the output and the retroactivity to the input of a phosphorylation-based insulation device by finding an optimal substrate concentration. Characterizing and improving the performance of insulation devices brings us a step closer to their successful implementation in biological circuits, and thus to modularity.(More)
— This paper considers the problem of attenuating retroactivity, that is, the effect of loads in biological networks and demonstrates that signal transduction cascades incorporating phosphotransfer modules have remarkable retroactivity attenuation ability. Uncovering the biological mechanisms for retroactivity attenuation is relevant in synthetic biology to(More)
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