Phillip Landrigan

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The disease burden from exposure to lead resulting in mild mental retardation (due to IQ point decreases) and cardiovascular outcomes (due to increases in blood pressure) was estimated at a global level. Blood lead levels were compiled from the literature for 14 geographical regions defined by the World Health Organization according to location and adult(More)
OBJECTIVES Mortality studies of lead workers have shown excesses of nonmalignant renal disease and cerebrovascular disease. Animal studies and one human study have shown excess kidney cancer. We have updated a mortality study of male lead smelter workers (n = 1990). METHODS An analysis was conducted using standard life table techniques. The updated(More)
Two children and 29 of 31 crew members aboard a grain freighter became acutely ill after inhaling the toxic fumigant phosphine; one child died. Predominant symptoms were headache, fatigue, nausea, vomiting, cough, and shortness of breath. Abnormal physical findings included jaundice, paresthesias, ataxia, intention tremor, and diplopia. Focal myocardial(More)
Three young men died of rapidly progressive pulmonary edema of delayed onset after inhalation of fumes from an accidental nitric acid explosion. Electron microscopy revealed altered neutrophils and necrotic endothelial cells in alveolar capillaries. Immunohistochemistry showed small and large serum proteins, including immunoglobulin M, in the edema fluid(More)
Immunobistochemical examination of pulmonary sarcoid showed clumps of immunoglobulin and complement in lesions from three patients revealed in all the presence and around the lesions of only one patient suffering from of clumps of immunoglobulin and complement in those allergic pulmonary alveolitis. This observation supports grandomas which were not(More)
A 42-year-old woman with extrinsic allergic alveolitis and worsening dyspnea was found to have an enlarged cardiac silhouette. Primary chylopericardium was diagnosed when pericardiocentesis yielded the characteristic milky-white fluid containing microscopic fat droplets. The pericardial effusion resolved with prednisone therapy.