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The role of microsomal NADPH:cytochrome P450 reductase (P450 reductase) and cytosolic NAD(P)H:quinone oxidoreductase 1 (NQO1 or DT-diaphorase) in the mutagenicity of benzo(a)pyrene-3,6-quinone (BP-3,6-Q) was studied using supF tRNA gene as the mutational target. pUB3 carrying the supF tRNA gene upon transformation into the Escherichia coli ES87 cells(More)
Acoustic techniques have been used for many years to find and locate leaks in buried water distribution systems. Hydrophones and accelerometers are typically used as sensors. Although geophones could be used as well, they are not generally used for leak detection. A simple acoustic model of the pipe and the sensors has been proposed previously by some of(More)
Benzo(a)pyrene and benzene are human carcinogens. The metabolic activation of these compounds into ultimate mutagenic and carcinogenic metabolites is prerequisite for their carcinogenic effects. In this report, the mutagenicity and carcinogenicity of hydroquinones of benzo(a)pyrene and benzene was investigated to address two important questions: (1) do(More)
The spatial correlation has previously been investigated for tonal and narrow-band sound fields. This letter presents an experimental investigation of the spatial correlation coefficients in a reverberation chamber driven by broadband signals. The main objective is to verify recent theoretical results for broadband spatial correlation in diffuse sound(More)
Mitomycin C (MMC) is a prototype bioreductive drug employed to treat a variety of cancers including head and neck cancer. Among the various enzymes, dicoumarol inhibitable cytosolic NAD(P)H:quinone oxidoreductase1 (NQO1) was shown to catalyse bioreductive activation of MMC leading to cross-linking of the DNA and cytotoxicity. However, the role of NQO1 in(More)
BACKGROUND People of South Asian origin suffer a high burden of premature myocardial infarction (MI). South Asians form a growing proportion of the Canadian population and preventive strategies to mitigate the risk of MI in this group are needed. Prior studies have shown that multimedia interventions are effective and feasible in inducing health behavior(More)
An aerofoil leading-edge profile based on wavy (sinusoidal) protuberances/tubercles is investigated to understand the mechanisms by which they are able to reduce the noise produced through the interaction with turbulent mean flow. Numerical simulations are performed for non-lifting flat-plate aerofoils with straight and wavy leading edges (denoted by SLE(More)
The presence of a "ladder" structure in the airfoil tonal noise was discovered in the 1970s, but its mechanism hitherto remains a subject of continual investigation in the research community. Based on the measured noise results and some numerical analysis presented in this letter, the variations of four types of airfoil tonal noise frequencies with the flow(More)
Ultrahigh molecular weight polyethylene (UHMWPE) fatigue is a critical factor affecting the longevity of total knee replacement (TKR) bearings. With the increased need for laboratory studies to mimic near in vivo conditions for accurate characterization of material performance, the present study investigated the role of hyaluronic acid (HA) in testing(More)
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