Phillip Hewitt

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Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will impact on the clinical utility of CDK8/19 inhibitors. We discovered two series of potent chemical probes with high selectivity for CDK8/19. Despite pharmacodynamic(More)
Techniques were developed for genetic characterization of Legionella pneumophila serogroup 1 by using restriction fragment length polymorphism analysis. Allozyme analysis provided an index of the discrimination achieved by restriction fragment length polymorphism. Isolates from human cases of legionellosis were examined by both methods, and their profiles(More)
There is a pressing and continued need for improved predictive power in preclinical pharmaceutical toxicology assessment as substantial numbers of drugs are still removed from the market, or from late-stage development, because of unanticipated issues of toxicity. In recent years a number of consortia have been formed with a view to integrating -omics(More)
Fertilized eggs ofHodotermes mossambicus took up water progressively during the last 15–16 days of the 24–25 day incubation period. Both the large eggs from founding pairs and the small eggs from mature colonies approximately doubled in weight. Infertile eggs, 50% of which survived for 14 days, showed a lower rate of water uptake. The eggs could take up(More)
The distribution of cellulase activity in the guts of workers of the termiteT. trinervoides was investigated. Approximately 70% of the total activity was found in the midgut and about 40% oif this occurs in the midgut wall. The appearance and distribution of gut bacteria is described. It is concluded that, in this species, the cellulase is synthesised by(More)
A serious bottleneck in the drug development pipeline is the inability of current pre-clinical toxicology evaluation methods to predict early on, and with good accuracy, that a drug candidate will have to be removed from development due to toxicology/safety issues. The InnoMed PredTox consortium attempted to address this issue by assessing the value of(More)
The control of caste formation in the harvester termiteHodotermes mossambicus (Hagen) was investigated. Normal laboratory colonies contained a primary reproductive pair, between 6.59 and 24.98% workers, 0.39 and 3.45% soldiers and 74.64 and 92.06% larvae. Supplementary reproductives did not develop in colonies deprived of their king and queen. Continuous(More)
The components of trail-laying and trailfollowing behaviour in the harvester termitesHodotermes mossambicus (Hagen) andTrinervitermes trinervoides (Sjöstedt) were investigated. In both species the trails are laid by pressing the third to sixth abdominal segments against the substratum. The trails are detected by olfactory receptors which are found on the(More)
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