Phillip E. Scuderi

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UNLABELLED This study was conducted to determine the efficacy and safety of four intravenous (I.V.) doses of dolasetron, an investigational 5-HT3 receptor antagonist, for the treatment of postoperative nausea and/or vomiting (PONV) after outpatient surgery under general anesthesia. This multicenter, randomized, double-blind trial compared the antiemetic(More)
STUDY OBJECTIVE To compare the efficacy of ondansetron, droperidol, or metoclopramide with placebo in preventing postoperative vomiting following strabismus surgery. STUDY DESIGN Randomized, double-blind, placebo-controlled clinical trial. SETTING University outpatient surgery center. PATIENTS 160 ASA physical status I and II children ages 1 to 12(More)
Objective.Pulse oximetry (SpO2) is the noninvasivestandard for monitoring arterial oxygen saturation in patients undergoinganesthesia, but is subject to external interference by motion artifact,peripheral vasoconstriction, and low cardiac output. We hypothesized thatoximetry signals could be acquired from the esophagus when peripheral pulseoximetry is(More)
The effect on survival of episodic hypoxemia was prospectively studied in 100 patients hospitalized on general medicine services of a large, tertiary care, university hospital. Pulse oximetry monitoring (POM) was initiated within 24 hours of admission and was maintained for approximately 24 hours independent of patient management. Hypoxemia lasting for at(More)
SERIOUS adverse drug reactions are frequently recognized only after postmarketing surveillance has begun. The most common cause of drug restriction or drug withdrawal from the marketplace is prolongation of the QT interval with an associated finding of polymorphic ventricular tachycardia, also known as torsades de pointes (TdP). At least nine structurally(More)
BACKGROUND Although prophylactic administration of antiemetics reduces the incidence of postoperative nausea, vomiting, or both (PONV), there is little evidence to suggest this improves patient outcomes. The authors hypothesized that early symptomatic treatment of PONV will result in outcomes, including time to discharge, unanticipated admission, patient(More)
OBJECTIVE To compare the clinical performance of three pulmonary artery oximetry catheters (Oximetrix 3, SAT-2, and HEMOPRO2) in intensive care unit (ICU) patients. DESIGN Unblinded comparison of performance over 24 h using an IL-282 CO-oximeter as a criterion standard. SETTING Multispecialty adult ICU at a university teaching hospital. PATIENTS(More)
We prospectively studied 23 patients undergoing carotid endarterectomy under regional (n = 13) or general (n = 10) anesthesia to determine the hemodynamic basis of increased frequency in the need for postoperative vasopressor support when regional anesthesia was used. Anesthesia and postoperative care were conducted without reference to hemodynamic data(More)
The purpose of this study was to test the hypothesis that using a 1:4 ratio of remifentanil to alfentanil, a remifentanil infusion would provide better suppression of intraoperative responses and comparable recovery profiles after ambulatory laparoscopic surgery than an alfentanil infusion, as part of total intravenous anesthesia. Two hundred ASA physical(More)