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In this paper, we propose a combination of mean-shift-based tracking processes to establish migrating cell trajectories through in vitro phase-contrast video microscopy. After a recapitulation on how the mean-shift algorithm permits efficient object tracking we describe the proposed extension and apply it to the in vitro cell tracking problem. In this(More)
BACKGROUND Epiluminescence microscopy (ELM) is a noninvasive clinical tool recently developed for the diagnosis of pigmented skin lesions (PSLs), with the aim of improving melanoma screening strategies. However, the complexity of the ELM grading protocol means that considerable expertise is required for differential diagnosis. In this paper we propose a(More)
The aim of the present review is to detail and analyze the pros and cons of in vitro tests available to quantify the anti-migratory effects of anti-cancer drugs for their eventual use in combating the dispersal of tumor cells, a clinical need which currently remains unsatisfied. We therefore briefly sum up why anti-migratory drugs constitute a promising(More)
Whether they are of low or high histopathological grade, human astrocytic tumors are characterized by a marked propensity to diffuse into large areas of normal brain parenchyma. This invasion relates mainly to cell motility, which enables individual cell migration to take place. The present study characterizes in vitro the gastrin-mediated effects on both(More)
The authors investigated whether cytometry-related variables generated by means of computer-assisted microscopic analysis of Feulgen-stained nuclei can contribute significant information toward the characterization of low-grade astrocytic tumor aggressiveness. This investigation was conducted using the nearest-neighbor rule (a traditional classification(More)
The current WHO classification places glioblastomas in the astrocytoma category. However, whether or not glioblastomas also show oligodendroglial differentiation remains a matter of controversy. This study investigates, at the morphonuclear level, the hypothesis that some glioblastomas (GBMs) may also represent the ultimate level of malignancy in the(More)
The present work investigates whether computer-assisted techniques can contribute any significant information to the characterization of astrocytic tumor aggressiveness. Two complementary computer-assisted methods were used. The first method made use of the digital image analysis of Feulgen-stained nuclei, making it possible to compute 15 morphonuclear and(More)
We present here a method giving a robust segmentation for in vitro cells observed under standard phase-contrast microscopy. We tackle the problem using the watershed transform. Watershed transform is known for its ability to generate closed contours and its extreme sensitivity to image borders. One main drawback of this method is over-segmentation. In order(More)
  • Bruno Marchal, Paul Gochet, Serge Pahaut, Georges Elencwajg, La Regrettée, Viviane Munyandamutsa +71 others
  • 1999
Table desmatì eres Remerciements v Introduction ix 1 L'hypothèse du computationnalisme 1 2 Comment fonctionne la démonstration ? 3 3 L'argument du déployeur universel 5 3.1 Le mécanisme entraˆıne une forme forte d'indéterminisme phé-5 Opinions et silences de la machine löbienne 33 5.1 Une " toute petite théorie de la conscience ". . vii de Lille , et d '(More)
Dissertation originale présentée par Colin MOLTER en vue de l'obtention du grade de docteur en Sciences Appliquées Le souverain de la mer du Sud s'appelait Rapidement [Shu]; le sou-verain de la mer du Nord s'appelait Soudainement [Hu]; le sou-verain du centre s'appelait Indistinction [Hun-tun]. Un jour Rapi-dement et Soudainement s'étaient rencontrés au(More)
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