Philippe Thiry

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OBJECTIVE To evaluate the distribution of cotinine in fetal fluids and serum during the first half of pregnancy, and compare the fetal and maternal cotinine levels in passive and active smokers. METHODS Maternal smoking status was determined by questionnaire in 85 pregnant women requesting abortion for psychosocial reasons between 7 and 17 weeks'(More)
Noninvasive indirect biochemical markers of liver fibrosis have gained popularity, but hepatologists are now facing the difficult dilemma of choosing among the 20 fibrosis markers that are now available.1 Stanislas Pol’s group2 claim that FIB-4, initially developed in a human immunodeficiency virus (HIV)-hepatitis C virus (HCV) coinfected population, is a(More)
The aims of the current study were (1) to study Neoral pharmacokinetics (PK) in stable lung recipients with or without cystic fibrosis (CF), (2) to compare Neoral PK between these two groups, and (3) to design Bayesian estimators for PK forecasting and dose adjustment in these patients using a limited number of blood samples. The individual PK of 19 adult(More)
OBJECTIVE To investigate the iron distribution between the maternal and embryonic compartments in the first trimester of pregnancy. METHODS Coelomic and amniotic fluids (AF) and maternal serum were collected from 36 apparently normal pregnancies at 7-13 weeks of gestation. Iron, transferrin, ferritin, and lactoferrin were measured in all samples. Iron(More)
OBJECTIVE Evaluation of a new fully automated antibody conjugated magnetic immunoassay (ACMIA) for whole blood cyclosporin (CsA) monitoring. METHOD Evaluation of the analytical performance of the ACMIA method and comparison to the Enzyme Multiplied Immunoassay (EMIT) method. RESULTS The analytical performance of the ACMIA and the EMIT methods was(More)
32. 4. Peck K, Sher YP, Shih JY, Roffler SR, Wu CW, Yang PC. Detection and quantitation of circulating cancer cells in the peripheral blood of lung cancer patients. Cancer Res 1998;58:2761–5. 5. Wallace B, Silvestri G, Sahai A, Hawes R, Hoffman B, Durkalski V, et al. Endoscopic ultrasound-guided fine needle aspiration for staging patients with carcinoma of(More)
BACKGROUND For mycophenolic acid (MPA), substantial inter- and intra-individual variability and drug interactions have been observed and therapeutic drug monitoring is now recommended. In this study, a MPA commercial Enzyme Multiplied Immunoassay Technique (EMIT) was evaluated and compared with the HPLC-UV reference method which is easily practicable in a(More)
C-reactive protein (CRP) is measured in two main clinical situations: inflammation, where levels in the range of 5-300 mg/L are expected, and, more recently, assessment of the cardiovascular risk, where concentrations between 0.1 and 10 mg/L shoud be determined. Few commercially available methods display a measuring range covering both zones and(More)