Philippe Talon

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The authors report a new case of infantile myoclonic encephalopathy with opsoclonus and neuroblastoma in a 14 months-old infant. Some immunologic abnormalities were found at the initial course of the disease. The review of 110 cases of "dancing-eyes syndrome" permit them to specify clinical features and prognosis but cannot explain the pathogenesis of this(More)
GH secretion and release are complex phenomena depending on activation of several genes, including those encoding GH, GHRH, and its receptor (GHRH-R). The GH gene, which is the most extensively analyzed sequence in patients with familial GH deficiency (GHD), represents the main known target of mutations. To test the involvement of the GHRH-R gene in this(More)
Among human immunodeficiency virus-1 (HIV-1) vertically infected children, two patterns of disease progression have been observed: about 25% develop a severe immunodeficiency within the first 2 years of life; the rest experience a slower progression, like adults. We have assessed infectious viral burden in infected neonates through the French National(More)
Two unrelated female cases of congenital insensitivity to pain with anhydrosis are presented. The first case was born from consanguineous parents. In both cases, onset of manifestation was observed in infancy with automutilation and recurrent fever. Both were mentally retarded. They underwent a peripheral nerve biopsy respectively at 3 and 33 years. A(More)
BACKGROUND The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D. METHODS Cases were children with T1D from the French Isis-Diab cohort. Controls were(More)
The authors report a case of meningitis following enteritis due to Salmonella Panama (group D). The severity of Salmonella infection is especially correlated with hematogenous dissemination, through a transitory lack of intestinal immunity. The limited efficacy of antibiotics in salmonellosis is responsible for an ambiguous preventive attitude towards(More)